Human Reproduction, Vol. 15, No. 6, 1247-1249,
June 2000
© 2000 European Society of Human Reproduction and Embryology
Ovulation side and cycle fecundity: a retrospective analysis of frozen/thawed embryo transfer cycles
1 Department of Obstetrics and Gynaecology, Oulu University Hospital, FIN-90220 Oulu and 2 The Infertility Clinic of Oulu, the Family Federation of Finland, Finland
The aim of the study was to evaluate a possible lateral difference in ovarian activity and its effect on cycle fecundity. A database was analysed retrospectively which covered 477 cycles in which frozen/thawed embryo transfer had been carried out. The cycles were spontaneous, with no hormonal treatment. Women with ovulation problems as a reason for infertility treatment were excluded. Factors investigated were the side of ovulation, endometrial thickness on cycle days 10–12 and on the day of embryo transfer, and pregnancy rate per embryo transfer. Ovulation was right-sided in 273 of the 477 cycles (57.2%) and left-sided in 204 of the cycles (42.8%) (95% CI 38.3–47.2, P = 0.002). In the age category of 30–37 years, covering 288 cycles, the incidence of left-sided ovulation was 126 (43.7%, 95% CI 38.0–49.5, P = 0.034). In this category, the endometrial thickness (±SD) was significantly greater on the day of embryo transfer (i.e. at time of implantation) when there had been left-sided ovulation compared with right-sided [9.6 mm (2.0) versus 9.1 mm (1.8), P = 0.037]. In addition, the pregnancy rate per embryo transfer was higher when ovulation had been on the left side [32/126 (25.2%) versus right side 24/162 (14.8%), P = 0.035, 95% CI 0.0122–0.199]. In conclusion, right-sided ovulation was more frequent than left-sided in the whole group. This is the first study to report that the side of ovulation has a clinical impact. These data support the hypothesis that the side of ovulation is significant in terms of embryo implantation.
Key words: cycle fecundity/endometrial thickness/frozen-thawed embryo transfer/ovulation side/pregnancy rate
3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Oulu University Hospital, FIN-90220 Oulu, Finland. E-mail: ijarvela{at}cc.oulu.fi
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