Human Reproduction, Vol. 15, No. 6, 1256-1260,
June 2000
© 2000 European Society of Human Reproduction and Embryology
Tumour necrosis factor 
concentrations in the peritoneal fluid of infertile women with minimal or mild endometriosis are lower in patients with red lesions only than in patients without red lesions
1 Human Reproduction Unit, Department of Obstetrics and Gynaecology and 2 Lisbon University Haematology and Immunology Centre, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1699 Lisboa Codex, Portugal
Tumour necrosis factor 
(TNF) of peritoneal fluid is believed to have important pro-inflammatory and angiogenic activities in the complex mechanisms of development of peritoneal endometriotic lesions. We have evaluated the concentrations of TNF and macrophages in peritoneal fluid of infertile women with minimal or mild endometriosis and related them to the presence of peritoneal red lesions alone (red lesions only group; n = 11) or their absence (non-red lesions group; n = 36). A group of 39 infertile normo-ovulatory patients with normal pelvic anatomy was used as controls. TNF concentrations did not differ between controls and either group of patients. Patients with red lesions only had significantly lower concentrations of TNF in peritoneal fluid (P < 0.05) and had a higher proportion of samples with undetectable concentrations (P < 0.05) than patients without red lesions. The significant difference in TNF concentrations was present when comparing the groups of patients in the proliferative phase but not in the secretory phase. Macrophage concentrations were not different in the groups. Our findings are compatible with an impairment of macrophage function and therefore lend support to the theory that an inappropriate immunological response of the peritoneal environment to regurgitated endometrium may play a part in the initial phases of endometriotic implants.
Key words:
minimal-mild endometriosis/peritoneal fluid/red lesions/tumour necrosis factor
3 To whom correspondence should be addressed at: Human Reproduction Unit, Department of Obstetrics and Gynaecology, Hospital de Santa Maria, Av. Prof. Egas Moniz,1699 Lisboa Codex, Portugal.E-mail: calhazjorge{at}mailtelepac.pt
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