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Human Reproduction, Vol. 15, No. 7, 1505-1508, July 2000
© 2000 European Society of Human Reproduction and Embryology

Oocyte donation in women cured of cancer with bone marrow transplantation including total body irradiation in adolescence

E.C. Larsen1,5, A. Loft1, K. Holm2, J. Müller3, V. Brocks4 and A.Nyboe Andersen1

1 Fertility Clinic, 2 Section of Paediatric Haematology and Oncology, 3 Department of Growth and Reproduction and 4 Division of Ultrasound in Obstetrics and Gynaecology, Juliane Marie Centre, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark

Female survivors of cancer in childhood and adolescence who have been treated with bone marrow transplantation including total body irradiation (TBI) are at high risk of developing ovarian follicular depletion and infertility. The lack of oocytes may be compensated for by oocyte donation but these patients also seem to have a uterine factor. Even though oestrogen replacement therapy is given, the growth of the uterus during adolescence is impaired. To our knowledge there have been no earlier reports of live births after oocyte donation in such patients. We report three cases of oocyte donation in women who, at a young age, were cured of haematological malignancies with bone marrow transplantation including TBI. In adolescence they developed ovarian failure and uterine volumes were assessed by ultrasonography. One woman with a uterus of almost normal size delivered a healthy child in the 37th week of gestation. Another woman with severely diminished uterine volume miscarried in the 17th week of gestation. The third woman has not yet conceived. Pregnancy achieved by oocyte donation is possible despite TBI in adolescence. However, the uterine factor is a concern and complications during pregnancy and preterm birth may be expected in these patients.

Key words: bone marrow transplantation/childhood cancer/oocyte donation/total body irradiation/uterine factor

5 To whom correspondence should be addressed.E-mail: Elisabeth.Larsen{at}dadnet.dk


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