Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (35)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Verco, S. J.S.
Right arrow Articles by diZerega, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Verco, S. J.S.
Right arrow Articles by diZerega, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 8, 1764-1772, August 2000
© 2000 European Society of Human Reproduction and Embryology

Development of a novel glucose polymer solution (icodextrin) for adhesion prevention: pre-clinical studies

Shelagh J.S. Verco1,3, Elizabeth M. Peers1, Colin B. Brown1, Kathleen E. Rodgers2, Norma Roda2 and Gere diZerega2

1 ML Laboratories PLC, Blaby, Leicestershire, LE8 4FA UK and 2 Livingston Research Institute, 1321 N. Mission Road, Los Angeles, CA 90033, USA

Intra-abdominal adhesion formation causes significant post-operative morbidity. Controlled studies using animal models have been carried out to assess the tolerability and preventive efficacy of icodextrin solution (a biodegradable, biocompatible, glucose polymer). Reduction of adhesion formation was first evaluated in a rabbit double uterine horn model, applying 10–75 ml of 7.5 and 20%, or 50 ml of 2.5–20% icodextrin solution post-operatively. Significant increases in adhesion free sites (P < 0.005) were observed with volumes >=25 ml, and at concentrations >=4%. Efficacy of 50 ml 4 and 20% icodextrin was then evaluated both during and after surgery, demonstrating significant reductions in adhesion formation (P < 0.002). In one study, intra- plus post-operative use of 4% icodextrin produced the greatest reduction of non-surgical site adhesions; in others, the post-operative effect was predominant. Post-surgical administration of 50 ml 4% icodextrin in a rabbit sidewall model also resulted in more adhesion-free animals, and a significant reduction (P < 0.001) in areas of adhesion formation and reformation. In a rat infection potentiation model, 4% icodextrin produced no difference in mortality, abscess formation or overall abscess score. These data suggest that 4% icodextrin offers a well-tolerated and effective means of reducing post-surgical adhesion formation.

Key words: glucose polymer/icodextrin/peritoneal adhesions/preclinical

To whom correspondence should be addressed at: ML Laboratories PLC, Blaby, Leicestershire, LE8 4FA, UK.E-mail: sjsverco{at}aol.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
C. Nappi, A. Di Spiezio Sardo, E. Greco, M. Guida, S. Bettocchi, and G. Bifulco
Prevention of adhesions in gynaecological endoscopy
Hum. Reprod. Update, July 1, 2007; 13(4): 379 - 394.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
S. A. Muller, K. H. Treutner, G. Haase, S. Kinzel, L. Tietze, and V. Schumpelick
Effect of Intraperitoneal Antiadhesive Fluids in a Rat Peritonitis Model
Arch Surg, March 1, 2003; 138(3): 286 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G.S. di Zerega, S.J.S. Verco, P. Young, M. Kettel, W. Kobak, D. Martin, J. Sanfilippo, E.M. Peers, A. Scrimgeour, and C.B. Brown
A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery
Hum. Reprod., April 1, 2002; 17(4): 1031 - 1038.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.