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Human Reproduction, Vol. 15, No. 8, 1813-1818, August 2000
© 2000 European Society of Human Reproduction and Embryology

Analysis of mid-trimester corticotrophin-releasing hormone and {alpha}-fetoprotein concentrations for predicting pre-eclampsia

T.N. Leung1,6, Tony K.H. Chung1, Gemma Madsen2, C.W.K. Lam3, Peggo K.W. Lam4, William A.W. Walters5 and Roger Smith2

1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, 2 The Mothers and Babies Research Centre, University of Newcastle, John Hunter Hospital, Australia, 3 Department of Chemical Pathology, 4 Centre for Clinical Trials and Epidemiological Research, The Chinese University of Hong Kong, Hong Kong, 5 Discipline of Reproductive Medicine and Department of Obstetrics and Gynaecology, University of Newcastle, John Hunter Hospital, Australia

The aims of this study were firstly to examine if corticotrophin-releasing hormone (CRH) concentrations in maternal plasma were significantly elevated in Chinese pregnancies complicated by pre-eclampsia, secondly to assess if this elevation could be detected in the mid-trimester before onset of clinical signs of the disease, and thirdly to evaluate the performance of using maternal CRH and/or {alpha}-fetoprotein (AFP) concentrations in the mid-trimester for prediction of pre-eclampsia. The first part of this study was tested in a cohort of 39 subjects. The CRH concentrations were significantly elevated in pregnant women complicated by pre-eclampsia. The second and third parts of the study involved a different cohort of 1021 subjects. Both CRH and AFP concentrations in the mid-trimester were significantly elevated in those who subsequently developed pre-eclampsia. However, when used for prediction of pre-eclampsia, neither the CRH nor AFP concentrations alone in the mid-trimester had strong predictive value. Although the combination of both tests improved the detection rate compared to the use of CRH alone, the small increase in the likelihood ratio from 1.9 to 2.6 did not suggest that the combination would be of great clinical value.

Key words: alpha-fetoprotein/corticotrophin releasing hormone/pre-eclampsia/prediction

6 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Hong Kong, China SAR. E-mail: dannytnleung{at}cuhk.edu.hk


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