Human Reproduction, Vol. 15, No. 8, 1819-1825,
August 2000
© 2000 European Society of Human Reproduction and Embryology
Obstetric outcome of singleton pregnancies after IVF: a matched control study in four Dutch university hospitals
1 Department of Obstetrics and Gynaecology, University Medical Centre, PO Box 85500, 3508 GA Utrecht, 2 Department of Obstetrics and Gynaecology, University Hospital Nijmegen, Nijmegen, 3 Department of Gynaecology and Reproductive Medicine, Leiden University Medical Centre, Leiden and 4 IVF Centre, Division of Endocrinology and Fertility, Institute of Endocrinology, Reproduction and Metabolism, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
In singleton pregnancies after IVF a high rate of preterm deliveries and an increased rate of small-for-gestational age (SGA) children in comparison to the general parturient population have been reported. However, due to differences between IVF mothers and their peers who conceived naturally, careful selection of the control group is necessary to assess whether IVF pregnancies really carry increased risks of adverse outcome. In our study 307 IVF pregnancies were compared with 307 control pregnancies after elaborate matching for an extensive number of maternal characteristics, as well as for the hospital that provided the obstetric care. Four Dutch university hospitals contributed to the study. In cases with spontaneous onset of labour, gestational age at delivery was 3 days shorter in the IVF group (275 versus 278 days, P = 0.05). The proportion of SGA was higher in the IVF group (16.2 versus 7.9%, P < 0.001). The combination of these two results denotes a distinct difference between IVF and control pregnancies. Placental weight was comparable in both groups.
Key words: IVF/matched control study/perinatal outcome/singleton pregnancies
5 To whom correspondence should be addressed. E-mail: J.Koudstaal{at}dog.azu.nl
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