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Human Reproduction, Vol. 15, No. 8, 1876-1877, August 2000
© 2000 European Society of Human Reproduction and Embryology

Letters to the editor

Hypotriploid tripronuclear oocytes with two polar bodies obtained after ICSI: is irregular chromatid segregation involved?

Bernd Rosenbusch1,3 and Michael Schneider2

1 Centre for Reproductive Medicine, Department of Gynecology and Obstetrics, University of Ulm, Prittwitzstrasse 43, 89075 Ulm/Donau, 2 Laboratory for Medical Genetics, Friedenstrasse 1, 89073 Ulm/Donau, Germany

Dear Sir,

A peculiarity of intracytoplasmic sperm injection (ICSI) is the occurrence of abnormally fertilized oocytes with three pronuclei (PN) and one (= the first) polar body (PB). It is generally accepted that these cells are digynic in their origin, the supernumerary PN being due to the non-extrusion of the second PB (Grossmann et al., 1997Go). Provided that the participating male and female gametes carry a normal, . . . [Full Text of this Article]

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B. Rosenbusch, M. Schneider, R. Kreienberg, and C. Brucker
Cytogenetic analysis of human zygotes displaying three pronuclei and one polar body after intracytoplasmic sperm injection
Hum. Reprod., November 1, 2001; 16(11): 2362 - 2367.
[Abstract] [Full Text] [PDF]