Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Treetampinich, C.
Right arrow Articles by de Kretser, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Treetampinich, C.
Right arrow Articles by de Kretser, D. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 15, No. 9, 2028-2032, September 2000
© 2000 European Society of Human Reproduction and Embryology

Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome

Chatchai Treetampinich1, Anne E. O'Connor1, Vivien MacLachlan2, Nigel P. Groome3 and David M. de Kretser1,4

1 1Monash Institute of Reproduction and Development, Monash University, 2 Monash IVF, Epworth Hospital, Richmond, Victoria, Australia and 3 School of Biological and Molecular Sciences, Oxford Brookes University, Oxford, UK

To compare maternal serum inhibin A concentrations in early pregnancy with pregnancy outcomes and treatment protocols, serum samples were collected from 237 women undergoing in-vitro fertilization (IVF) and embryo transfer cycles. Samples were collected on day 16 after oocyte retrieval for ß human chorionic gonadotrophin (HCG) pregnancy testing and inhibin A measurement. The samples were divided into non-pregnant (n = 128) and pregnant (n = 109) groups, the pregnancies were followed and outcomes determined. Inhibin A concentrations were significantly lower in non-pregnant women than in women with ongoing pregnancies (P < 0.001) and those resulting in spontaneous abortions (P < 0.001). In ongoing pregnancies, inhibin A concentrations were significantly lower in the absence of functioning ovaries (donor oocyte/embryo) (P < 0.01) and in natural cycles (frozen–thawed embryo transfer) (P < 0.01) compared with concentrations after ovarian stimulation. Further, since inhibin A concentrations were not significantly different between singleton and multiple pregnancies in the ovarian stimulation protocol, the size of the early trophoblast does not appear to influence the secretion of inhibin A. These data strongly support the concept that the corpus luteum is a major source of circulating inhibin A in early pregnancy. Additionally, low concentrations of serum inhibin A may be useful in predicting ßHCG-positive preclinical `biochemical' pregnancies.

Key words: corpus luteum/inhibin A/in-vitro fertilization/outcomes/pregnancy

4 To whom correspondence should be addressed at: Monash Institute of Reproduction and Development, Monash Medical Centre,246 Clayton Road, Clayton, Victoria 3168, Australia. Email: David.de.Kretser{at}med.monash.edu.au


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
E. Kirk, A. T. Papageorghiou, B. Van Calster, G. Condous, N. Cowans, S. Van Huffel, D. Timmerman, K. Spencer, and T. Bourne
The use of serum inhibin A and activin A levels in predicting the outcome of 'pregnancies of unknown location'
Hum. Reprod., October 1, 2009; 24(10): 2451 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
J. Cartwright, W C. Duncan, H. O D Critchley, and A. W Horne
Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities
Reproduction, July 1, 2009; 138(1): 9 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
S. Muttukrishna, C. Bearfield, J. Johns, and E. Jauniaux
Inhibin, activin, follistatin, activin receptors and {beta}-glycan gene expression in the villous tissue of miscarriage patients
Mol. Hum. Reprod., November 1, 2004; 10(11): 793 - 798.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Tong, L. Rombauts, A. Mulder, B. Marjono, J. L. Onwude, and E. M. Wallace
Increased Day 15-17 Serum Pro-{alpha}C Inhibin Levels Specific to Successful Pregnancy
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4464 - 4468.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Lahiri, C.J. Anobile, P. Stewart, and W.L. Ledger
Changes in circulating concentrations of inhibins A and pro-{alpha} C during first trimester medical termination of pregnancy
Hum. Reprod., April 1, 2003; 18(4): 744 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Muttukrishna, E. Jauniaux, N. Greenwold, H. McGarrigle, S. Jivraj, S. Carter, S. Elgaddal, N. Groome, and L. Regan
Circulating levels of inhibin A, activin A and follistatin in missed and recurrent miscarriages
Hum. Reprod., December 1, 2002; 17(12): 3072 - 3078.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. Creus, J. Ordi, F. Fabregues, R. Casamitjana, J. A. Vanrell, and J. Balasch
Mid-luteal serum inhibin-A concentration as a marker of endometrial differentiation
Hum. Reprod., July 1, 2001; 16(7): 1347 - 1352.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.