Human Reproduction, Vol. 15, No. 9, 2033-2036,
September 2000
© 2000 European Society of Human Reproduction and Embryology
Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia
Department of Maternal–Fetal Medicine, Division of Paediatrics, Obstetrics & Gynaecology, Imperial College School of Medicine, Chelsea & Westminster Hospital, London, UK
Leptin concentrations have been found to be elevated in cross-sectional studies of established pre-eclampsia. Circulating concentrations of leptin were measured in a cross-sectional study to confirm these findings (19 women with pre-eclampsia and 13 normal pregnant controls) and in a longitudinal study to establish the timing of the increase in leptin concentrations (samples obtained at 16, 20, 24, 28, 32, 36 and 38 weeks gestation from eight women who went on to develop pre-eclampsia and seven normal pregnant controls). In the cross-sectional study, plasma leptin concentrations were significantly greater in women with pre-eclampsia than in normal controls (P = 0.001). In the longitudinal study, it was found that circulating leptin concentrations rose gradually to 32 weeks and thereafter declined slightly in normals. The concentrations in women destined to develop pre-eclampsia were consistently higher from 20 weeks gestation (P = 0.04–0.003) and, in contrast to the normal controls, rose markedly from 32 weeks as pre-eclampsia developed. This study confirms that plasma leptin concentrations are increased in established pre-eclampsia and reports for the first time that leptin concentrations are elevated before pre-eclampsia is clinically evident.
Key words: leptin/pre-eclampsia/pregnancy
1 To whom correspondence should be addressed at: Department of Maternal–Fetal Medicine, Division of Paediatrics Obstetrics & Gynaecology, Imperial College School of Medicine, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 8NH, UK. E-mail: n.anim{at}ic.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. D. Briana and A. Malamitsi-Puchner Reviews: Adipocytokines in Normal and Complicated Pregnancies Reproductive Sciences, October 1, 2009; 16(10): 921 - 937. [Abstract] [PDF]
|
|
|
|
 |
|
 G. M. Raso, G. Bianco, A. Iacono, E. Esposito, G. Autore, M. C. Ferrante, A. Calignano, and R. Meli Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation J. Endocrinol., September 1, 2007; 194(3): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Magarinos, V. Sanchez-Margalet, M. Kotler, J. C. Calvo, and C. L. Varone Leptin Promotes Cell Proliferation and Survival of Trophoblastic Cells Biol Reprod, February 1, 2007; 76(2): 203 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Shibata, R. W. Powers, A. Rajakumar, F. von Versen-Hoynck, M. J. Gallaher, D. L. Lykins, J. M. Roberts, and C. A. Hubel Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1009 - E1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Haugen, T. Ranheim, N. K. Harsem, E. Lips, A. C. Staff, and C. A. Drevon Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E326 - E333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Henson and V. D. Castracane Leptin in Pregnancy: An Update Biol Reprod, February 1, 2006; 74(2): 218 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Schulz and E. P. Widmaier The Effect of Leptin on Mouse Trophoblast Cell Invasion Biol Reprod, December 1, 2004; 71(6): 1963 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. W. Seely and C. G. Solomon Insulin Resistance and Its Potential Role in Pregnancy-Induced Hypertension J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2393 - 2398. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Anim-Nyame, J. Gamble, S. R. Sooranna, M. R. Johnson, and P. J. Steer Microvascular permeability is related to circulating levels of tumour necrosis factor-{alpha} in pre-eclampsia Cardiovasc Res, April 1, 2003; 58(1): 162 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Reimer, D. Koczan, B. Gerber, D. Richter, H.J. Thiesen, and K. Friese Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes Mol. Hum. Reprod., July 1, 2002; 8(7): 674 - 680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Reis, D. D'Antona, and F. Petraglia Predictive Value of Hormone Measurements in Maternal and Fetal Complications of Pregnancy Endocr. Rev., April 1, 2002; 23(2): 230 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.M. Laird, N.D. Quinton, B. Anstie, T.C. Li, and A.I.F. Blakemore Leptin and leptin-binding activity in women with recurrent miscarriage: correlation with pregnancy outcome Hum. Reprod., September 1, 2001; 16(9): 2008 - 2013. [Abstract] [Full Text] [PDF]
|
|