Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sudik, R.
Right arrow Articles by Wieacker, P.F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sudik, R.
Right arrow Articles by Wieacker, P.F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 16, No. 1, 56-58, January 2001
© 2001 European Society of Human Reproduction and Embryology

Chimerism in a fertile woman with 46,XY karyotype and female phenotype: Case report

R. Sudik1, S. Jakubiczka2, F. Nawroth1, E. Gilberg3 and P.F. Wieacker2,4

1 Department of Obstetrics and Gynecology, Klinikum Neubrandenburg, 2 Institute of Human Genetics, Otto-von-Guericke University Magdeburg, and 3 Department of Pediatrics, Klinikum Neubrandenburg, Germany

We report on the unexpected finding of a 46,XY karyotype in a 30 year-old woman with normal ovarian function and a former pregnancy at 17 years of age. Chromosome analysis was performed prior to intracyoplasmic sperm injection (ICSI), due to infertility of her husband. Repeated chromosome analysis in lymphocytes of the female resulted in a normal male karyotype. Fluorescence in-situ hybridization (FISH) analysis of cultured lymphocyte interphase nuclei detected in 99% of the cells one X and one Y chromosome-specific signal respectively, whereas two X chromosome-specific signals were observed in only 1% of the nuclei. Chromosome analysis of fibroblasts of ovarian and muscular tissues as well as of skin revealed a normal female karyotype (46,XX). Chimerism could be proven by variable number of tandem repeats (VNTR) analysis. Since the case history of the patient revealed that her twin brother died shortly after birth, it can be assumed that chimerism is caused by feto–fetal transfusion during pregnancy and delivery of the proposita.

Key words: chimerism/fertility/FISH/VNTR

4 To whom correspondence should be addressed at: Universitätsklinikum Magdeburg, Institut für Humangenetik, Leipziger Strasse 44, 39120 Magdeburg, Germany. E-mail: Peter.Wieacker{at}medizin.uni-magdeburg.de


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
A M Stevens
Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?
Lupus, November 1, 2006; 15(11): 820 - 826.
[Abstract] [PDF]

Home page
 Hum ReprodHome page
C. E. Boklage
Embryogenesis of chimeras, twins and anterior midline asymmetries
Hum. Reprod., March 1, 2006; 21(3): 579 - 591.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.