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Human Reproduction, Vol. 16, No. 10, 2195-2197, October 2001
© 2001 European Society of Human Reproduction and Embryology

The accuracy of serum interleukin-6 and tumour necrosis factor as markers for ovarian torsion

Shlomo B. Cohen1,3, Arnaud Wattiez2, David Stockheim1, Daniel S. Seidman1, Arie L. Lidor1, Shlomo Mashiach1 and Mordechai Goldenberg1

1 J.Buchman Maternity Center, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine and Tel-Aviv University, Israel and 2 Department of Obstetrics, Gynaecology and Reproductive Medicine, Polyclinique de l'Hotel-Dieu, Clermont-Ferrand, France

BACKGROUND: The aim of this study was to investigate a possible role for interleukin-6 (IL-6) and tumour necrosis factor (TNF-{alpha}) as pre-operative markers for the diagnosis of ovarian torsion. METHODS: Twenty consecutive patients admitted to the gynaecological emergency room with suspected clinical diagnosis of ovarian torsion were prospectively assigned to the study. Blood samples were drawn pre-operatively and examined for serum concentrations of IL-6 and TNF-{alpha}. Surgeons were blinded to laboratory results prior to laparoscopy. RESULTS: The pre-operative diagnosis of ovarian torsion was confirmed during an urgent diagnostic laparoscopy in 8 (40%) patients. The surgical diagnosis among the remaining 12 patients was a large ovarian cyst not in torsion. In six out of eight (75.0%) patients with ovarian torsion serum IL-6 concentrations were elevated. None of the 12 patients without torsion had elevated serum IL-6 concentrations. This difference was statistically significant (P < 0.001). There was no significant difference in the proportion of women with elevated serum TNF-{alpha} concentrations, two of eight (25.0%) patients with torsion and four of 12 (33.3%) control cases. CONCLUSIONS: Elevated serum IL-6 concentrations, but not serum TNF-{alpha} concentrations, were significantly associated with the occurrence of ovarian torsion. In patients with vague clinical signs of ovarian torsion, serum IL-6 might help to distinguish which patients should undergo diagnostic laparoscopy.

Key words: interleukin-6/markers/ovarian torsion/tumour necrosis factor-{alpha}

3 To whom correspondence should be addressed at: Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, 52621 Israel. E-mail: s_cohen_eylon{at}hotmail.com


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