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Human Reproduction, Vol. 16, No. 11, 2379-2383, November 2001
© 2001 European Society of Human Reproduction and Embryology

Is there any benefit from the culture of a single oocyte to a blastocyst-stage embryo in unstimulated cycles?

Veljko Vlaisavljevic1,2, Borut Kovacic1, Milan Reljic1, Vida Gavric Lovrec1 and Mojca Cizek Sajko1

1 Department of Reproductive Medicine and Gynaecologic Endocrinology, Maribor Teaching Hospital, Ljubljanska 5, SI 2000 Maribor, Slovenia

BACKGROUND: The aim of the study was to test the influence of 2- and 5-day cultivation of a single oocyte on the pregnancy rate in a non-stimulated cycle. METHODS: A retrospective chart review of 391 consecutive patients undergoing IVF and intracytoplasmic sperm injection in unstimulated cycles was performed. The embryos were kept in MediCult universal IVF medium for day 2 transfers and in BlastAssist System for day 5 transfers. RESULTS: The oocyte recovery rate in the group for 2-day cultivation and in the group for 5-day cultivation was similar, being 79.4 (162/204) and 83.6% (154/187) respectively. The same is true of the fertilization rate (73.8 versus 77.7%). The blastulation rate was 52.8%. The embryo transfer rate per cycle was higher when day 2 embryos were transferred: 64.8% (105/162) compared with 35.7% (55/154) if blastocyst-stage embryos were transferred. The pregnancy rate per transferred embryo was higher when a blastocyst was transferred (40.0%) instead of a day 2 embryo (23.8%). CONCLUSION: The expected pregnancy rate calculated per embryo available on day 2 of cultivation was similar in both groups (23.8 versus 22.2%) and it was not affected by oocyte culture to the blastocyst stage.

Key words: blastocyst/embryo transfer/sequential media/single embryo/unstimulated cycle

2 To whom correspondence should be addressed. E-mail: vlai{at}sb-mb.si


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