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Human Reproduction, Vol. 16, No. 11, 2384-2389, November 2001
© 2001 European Society of Human Reproduction and Embryology

Evaluation of pronuclear morphology as the only selection criterion for further embryo culture and transfer: results of a prospective multicentre study

M. Montag, H. van der Ven1 and on behalf of the German Pronuclear Morphology Study Group,*

BACKGROUND: The aim was to study zygote evaluation based on pronuclear morphology under the German embryo protection law, according to which only a maximum of three zygotes are allowed to be cultured for embryo transfer. METHODS: In this prospective multicentre study, a total of 512 treatment cycles was performed at 10 centres, between November 1999 and October 2000. Zygotes were classified into seven patterns (0A, 0B and 1–5). Pattern 0A and 0B zygotes were preferentially used for further culture and transfer. RESULTS: Cycles with transfer of at least one embryo derived from pattern 0B, but not pattern 0A, resulted in significantly higher pregnancy (37.9%) and implantation rates (20.5%) compared with non-pattern 0B cycles (26.4 and 15.7%; P < 0.05 and P < 0.01 respectively). In younger patients (aged <=35 years), significantly more 0B zygotes were available for transfer than in older patients (34.2 versus 25.8%; P < 0.005). CONCLUSIONS: From these data, it is concluded that evaluation of pronuclear morphology is beneficial, especially for countries with legal restrictions regarding embryo selection.

Key words: ICSI/implantation/IVF/maternal age/pronuclear morphology

1 To whom correspondence should be addressed at: Universitäts-Frauenklinik Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany. E-mail: m.montag{at}uni-bonn.de

* Participating centres: V.Blumenauer, J.Schuster, F.A.Hmeidan, Zentrum f. Reproduktionsmedizin, Goldschmidstr. 30, D-04103 Leipzig; C.Balko, R.Sudik, Klinik f. Gynäkologie u. Geburtshilfe, Salvador-Allende-Str. 30, D-17036 Neubrandenburg; E.Schanze, K.Marx, R.J.van Kooij, U.Weidner, Praxis Verhoeven Scholtes Marx Wohlers Schulte, Neusser Str. 111, D-40219 Düsseldorf; J.Hirchenhain, J.S.Krüssel, P.Bielfeld, Universitäts-Frauenklinik, Moorenstr. 5, D-40225 Düsseldorf; B.Herrmann, J.Tigges, Praxis Dres Tigges Doerner Tuchel, Rheydter Str. 143, D-41515 Grevenbroich; P.Gaßner, A.Schepers, H.M.Behre, Institut f. Reproduktionsmedizin, Universität Münster, Domagkstr. 11, D-48129 Münster; M.Montag, M.Kupka, K.van der Ven, H.van der Ven, Abt. Gyn. Endokrinol. u. Reproduktionsmedizin, Universitäts-Frauenklinik, Sigmund-Freud-Str. 25, D-53105 Bonn; M.Greuner, S.Roth, M.Thaele, Praxis Happel Thaele Happel, Kaiserstr. 7, 66111 Saarbrücken; I.Eberhardt, D.Seehaus, T.Strowitzki, Abt. Gyn. Endokrinol. u. Fertilitätsstörungen, Universitäts-Frauenklinik, Voßstr. 9, D-69115 Heidelberg; D.Ecke, C.Keck, Breckwoldt, Universitäts-Frauenklinik, Hugstetter Str. 55, D-79106 Freiburg


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