Human Reproduction, Vol. 16, No. 12, 2583-2586,
December 2001
© 2001 European Society of Human Reproduction and Embryology
Ovarian response during IVF–embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3 cm in diameter
Department of Obstetrics, Gynaecology and Reproductive Medicine, CHU Bd. Leon Malfreyt 63058 Clermont Ferrand, Cedex 1 France
BACKGROUND: Ovarian response during IVF cycles after laparoscopic ovarian cystectomy for endometriotic cysts >3 cm is controversial. A retrospective study was designed to study this problem. METHODS: At laparoscopy, endometriomas >3 cm were treated by ovarian cystectomy, whilst adhesions and peritoneal endometriosis were treated using conventional techniques. Ovarian stimulation was achieved with clomiphene and gonadotrophins or with gonadotrophins after a desensitization with gonadotrophin-releasing hormone agonists. Three groups of patients were retrospectively selected from an IVF–embryo transfer database: patients who underwent laparoscopic ovarian cystectomy for an endometrioma >3 cm (Group A, n = 41), patients with endometriosis without ovarian endometrioma (Group B, n = 139) and patients with tubal infertility (Group C, n = 59). RESULTS: The groups did not differ in age. In the first IVF cycle, the mean (± SD) numbers of oocytes and of embryos were 9.4 ± 6.2 and 4.7 ± 3.6 respectively in group A and 11.6 ± 7.5 and 5.1 ± 4.9 in group B (not significant). The results did not differ in cycles 2 and 3 or when compared according to age. No difference was found when comparing patients with endometriosis and patients with tubal infertility. CONCLUSION: The number of oocytes and embryos obtained was not significantly decreased by laparoscopic cystectomy, suggesting that in experienced hands this procedure may be a valuable surgical tool for the treatment of large ovarian endometriomas. However, great care must be taken to avoid ovarian damage.
Key words: cystectomy/endometriosis/IVF–embryo transfer/laparoscopy/ovary
1 To whom correspondence should be addressed. E-mail: mcanis{at}chu-clermontferrand.fr
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