Human Reproduction, Vol. 16, No. 12, 2610-2615,
December 2001
© 2001 European Society of Human Reproduction and Embryology
Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles*,**
1 Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 2 Reproductive Medicine Associates of New Jersey, Morristown, NJ and 3 Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC, USA
BACKGROUND: Endometrial cavity fluid (ECF) is occasionally observed during assisted reproductive technology (ART) cycles. However, few reports have described its prevalence or significance. METHODS AND RESULTS: We examined the relationships between ECF, clinical pregnancy rate (CPR), tubal factor infertility and ultrasound-visible (USV) hydrosalpinges. In 843 ART cycles involving 721 patients, ECF was observed during stimulation in 57 cycles and after human chorionic gonadotrophin (HCG) administration in 12 cycles, with an overall incidence of 8.2% (69/843). When ECF was observed during stimulation, the cancellation rate due to poor ovarian response was significantly higher (29.8 versus 16.9%, P <0.05) and the CPR per started cycle was significantly lower (26.3 versus 42.4%, P <0.05) than cycles without ECF. When ECF developed after HCG administration, the CPR was similar compared with that of the group for which ECF was not observed. In the 327 cycles involving tubal factor infertility patients, USV hydrosalpinges were noted in 71 cycles (71/327; 21.7%), and ECF developed in five of those cycles (5/71; 7.0%). A total of 27 cycles during which ECF developed (27/57, 47.4%) involved non-tubal factor patients. CONCLUSIONS: ECF during stimulation was associated with increased cancellation rates and lower CPRs per started cycle, and was not associated with USV hydrosalpinges. Furthermore, ECF observed after HCG administration did not impact CPR and may represent a different clinical entity.
Key words: cancellation rates/endometrium/fluid/hydrosalpinx/IVF
4 To whom correspondence should be addressed at: Walter Reed Army Medical Center, Room 2J06, Building 2, Department of Obstetrics and Gynecology, 6900 Georgia Avenue, NW, Washington, DC 20307, USA. E-mail: mark.leondires{at}na.amedd.army.mil
* The views expressed in this article are those of the author(s) and do not reflect the official policy or position of the Department of the Army, Department of Defense, nor the US Government.
** Presented at the 56th Annual Meeting of the American Society of Reproductive Medicine, San Diego, California, USA, October, 2000.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Akman, H. F. Erden, and M. Bahceci Endometrial fluid visualized through ultrasonography during ovarian stimulation in IVF cycles impairs the outcome in tubal factor, but not PCOS, patients Hum. Reprod., April 1, 2005; 20(4): 906 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Strandell and A. Lindhard Why does hydrosalpinx reduce fertility?: The importance of hydrosalpinx fluid Hum. Reprod., May 1, 2002; 17(5): 1141 - 1145. [Abstract] [Full Text] [PDF]
|
|