Human Reproduction, Vol. 16, No. 12, 2705-2709,
December 2001
© 2001 European Society of Human Reproduction and Embryology
Moderate alcohol consumption and waiting time to pregnancy
1 Danish Epidemiology Science Centre at the Department of Epidemiology Research, Statens Serum Institut, 5, Artillerivej, DK-2300 Copenhagen S, 2 Department of Social Medicine, Department of Public Health, University of Copenhagen, 3, Blegdamsvej, DK-2200 Copenhagen N, 3 Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen Hospital Corporation, Kommunehospitalet, DK-1399 Copenhagen K and 4 Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, 6, Vennelyst Boulevard, DK-8000 Aarhus C, Denmark
BACKGROUND: Recent research indicates that even a moderate consumption of alcohol in women trying to become pregnant is associated with longer waiting time to pregnancy. The findings, though, are based upon few observations. METHODS: Self-reported data on alcohol intake and waiting time to pregnancy (0–2, 3–5, 6–12 and >12 months) was used for 39 612 pregnant women, recruited to the Danish National Birth Cohort within the first 24 weeks of pregnancy from 1997 to 2000. Main outcome measures were odds ratios (OR) for a prolonged waiting time to pregnancy according to alcohol intake. RESULTS: In nulliparous women neither moderate nor high alcohol intake was related with longer waiting time to pregnancy compared with a low intake. In parous women, a modest association was seen only among those with an intake of >14 drinks per week (subfecundity OR 1.3; 95% confidence interval 1.0–1.7). Women who reported no alcohol intake had a slightly longer waiting time (subfecundity OR 1.2; 95% confidence interval 1.1–1.3) than women with a moderate intake of alcohol. CONCLUSIONS: Our findings do not corroborate recent results suggesting a marked reduction in fecundity associated with a moderate intake of alcohol.
Key words: alcohol/birth cohort/fecundity/time to pregnancy
5 To whom correspondence should be addressed. E-mail: mju{at}ssi.dk
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