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Human Reproduction, Vol. 16, No. 3, 593-595, March 2001
© 2001 European Society of Human Reproduction and Embryology

Letters to the editor

Meta analysis on rFSH versus uFSH

Henk J. Out,1

Organon Laboratories, Science Park, Cambridge CB4 0FL, UK Eric H.M.Hoomans and W.N.G.M.de Laat N.V. Organon, Oss, The Netherlands

Dear Sir,

We would like to react on the ongoing discussion of the meta-analysis on all performed recombinant versus urinary FSH (rFSH versus uFSH) clinical trials in assisted reproduction (Daya and Gunby, 1999Go) by making the following points.

We endorse the initiative by Daya and Gunby in performing this meta-analysis. It was reassuring to see that their meta-analysis basically confirmed our own analysis using only follitropin beta data, i.e. that rFSH results in statistically and clinically significantly more pregnancies when compared with urinary gonadotrophins (Out et al., 1997aGo).

However, we very much regret that the paper has been misinterpreted by many people as showing that follitropin alpha is more superior to uFSH than follitropin beta. Although Daya . . . [Full Text of this Article]

Notes

References

Salim Daya and Joanne Gunby

Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada


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