Human Reproduction, Vol. 16, No. 5, 868-870,
May 2001
© 2001 European Society of Human Reproduction and Embryology
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial
IVF Unit, German Hospital, Istanbul, Turkey
The management of poor responders in IVF has always been a big problem. The ideal approach has yet to be formulated. In this study we aim to compare two alternative stimulation protocols. A total of 48 poor responder patients described from previous cycles were included and grouped into two: group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 µg s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3; group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration. While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance. The impact of these two regimens in ovarian stimulation of poor responders seem to be same and to establish these results further randomized studies with larger sample sizes are required.
Key words: cetrorelix/GnRH antagonist/IVF embryo transfer/microdose GnRH agonist flare-up/poor responders
1 To whom correspondence should be addressed at: Abdi Ipekci Cad, Azer Is Merkezi, No=44, Nisantasi, Istanbul, Turkey.E-mail: mbahceci{at}hotmail.com
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