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Human Reproduction, Vol. 16, No. 6, 1218-1220, June 2001
© 2001 European Society of Human Reproduction and Embryology

Azoospermia due to testicular amyloidosis in a patient with familial Mediterranean fever: Case report

Ronit Haimov-Kochman1,4, Diana Prus2 and Eldad Ben-Chetrit3

1 Department of Obstetrics and Gynecology, 2 Department of Pathology, Hadassah University Hospital, Mount Scopus and 3 Department of Medicine, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel

We describe a patient suffering from familial Mediterranean fever (FMF) who presented to our clinic with secondary infertility of 2 years due to amyloid A amyloidosis. His spermiogram disclosed azoospermia. A testicular biopsy revealed hyalinized tubules devoid of full spermatogenesis and containing abundant amyloid, confirmed by Congo red stain. We suggest that testicular amyloidosis be taken into consideration when dealing with azoospermic FMF patients. In view of the progressive nature of amyloid accumulation in the testis we propose to follow routinely the spermiogram of FMF patients with renal amyloidosis. Furthermore, consideration of sperm cryopreservation is suggested in these cases. In FMF patients with azoospermia consideration of testicular biopsy is recommended as early as possible in order to increase the chance of sperm retrieval.

Key words: amyloidosis/azoospermia/recurrent polyserositis/testicular biopsy

4 To whom correspondence should be addressed. E-mail: eldad{at}hadassah.org.il


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