Human Reproduction, Vol. 16, No. 7, 1391-1396,
July 2001
© 2001 European Society of Human Reproduction and Embryology
Friendly IVF: patient opinions
1 Fertility Clinic and 2 Perinatal Epidemiological Research Unit, Department of Gynaecology and Obstetrics, Aarhus University Hospital, Skejby Sygehus, Aarhus, Denmark
BACKGROUND: The present trend towards low stimulation protocols in IVF calls for evaluation of patient attitudes. METHODS: This study compared results of a 23-item questionnaire mailed to 167 patients receiving a low stimulation type of regimen (LS-IVF) (unstimulated cycle or clomiphene) and to 116 patients treated by a standard protocol (S-IVF) (long-down regulation with gonadotrophin-releasing hormone analogue and FSH or human menopausal gonadotrophin). RESULTS: Around two-thirds of all responders in both groups deemed side-effects important, but side-effects and stress associated with hormone treatment were more prevalent in patients receiving S-IVF than LS-IVF. Stress due to cycle cancellation was acceptable, mild or not perceptible in significantly (P < 0.005) more patients receiving LS-IVF [48% (36/75)] compared with patients having S-IVF [26% (8/31)]. Of patients having tried the LS-IVF protocol, 93% (125/135) would suggest either LS-IVF or a sequence of this and S-IVF as a future treatment `package' compared with only 53% (33/63) in the S-IVF group (
2 = 43.08, P < 0.0001). The LS-IVF group showed a significant trend towards acceptance of higher number of treatment cycles. CONCLUSIONS: The patients seemed to prefer the simplicity and short duration of a low stimulation regimen in spite of drawbacks such as a high risk of cycle cancellations and accordingly the necessity for more treatment cycles.
Key words: clomiphene citrate/IVF/long down-regulation/unstimulated cycle
3 To whom correspondence should be addressed at: Fertility Clinic, Skejby Sygehus, DK-8200 Aarhus N, Denmark.E-mail: astrid.hoejgaard{at}dadlnet.dk
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