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Human Reproduction, Vol. 16, No. 8, 1553-1555, August 2001
© 2001 European Society of Human Reproduction and Embryology

OPINION

Disposition of sperm donors with resultant abnormal pregnancies

Jeffrey A. Kuller,1, William R. Meyer, Kyle D. Traynor and Katherine E. Hartmann

Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA.

Abstract

We wished to determine how clinicians manage sperm donors whose offspring have chromosomal or structural abnormalities. A directed, multiple-choice survey was given to reproductive endocrinologists and obstetrical geneticists to assess management of sperm donors whose offspring have chromosomal or structural abnormalities. The questionnaire was completed by 66 reproductive endocrinologists and obstetrical geneticists. Abnormalities and the most common inheritance modes included: Trisomy 21 (aneuploidy, maternal origin), Turner syndrome (aneuploidy, paternal origin), cleft lip/palate (multifactorial), VATER sequence (vertebral defects, imperforate anus, tracheo-esophageal fistula, radial and renal dysplasia, sporadic inheritance), and Hurler syndrome (autosomal recessive). Response choices were: (i) remove donor from programme, (ii) inform potential recipients of prior pregnancy outcomes and continue to use donor, or (iii) further study donor to assess karyotype/mutations. Inheritance mode appeared to influence decisions to remove donors from sperm banks; however, no clear consensus was noted. Guidelines exist for screening potential gamete donors, but not for managing donors whose offspring has a chromosomal or structural abnormality. Guidelines must be developed to manage sperm donors with untoward pregnancy outcomes.

Key words: sperm donors/gamete donors/chromosomal abnormality/structural abnormality

Notes

1 To whom correspondence should be addressed at: OB/Gyn–214 MacNider Building, CB#7516, UNC-Chapel Hill, NC 27599-7516, USA. Email: Jeffrey_Kuller{at}med.unc.edu


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