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Human Reproduction, Vol. 16, No. 9, 1866-1874, September 2001
© 2001 European Society of Human Reproduction and Embryology

Serological investigation of Mycoplasma genitalium in infertile women

Helle Friis Clausen1,2,6, Jens Fedder3,4, Mette Drasbek5, Pernille K. Nielsen1, Bente Toft3, Hans Jakob Ingerslev4, Svend Birkelund1 and Gunna Christiansen1

1 Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, 2 Department of Molecular and Structural Biology, University of Aarhus, DK-8000 Aarhus C, 3 The Fertility Clinic, Braedstrup Hospital, DK-8740 Braedstrup, 4 The Fertility Clinic, Skejby Hospital, DK-8200 Aarhus N and 5 Loke Diagnostic ApS, Science Park, Gustav Wiedsvej 10C, DK-8000 Aarhus C, Denmark

BACKGROUND: The role of Mycoplasma genitalium in the pathogenesis of pelvic inflammatory disease has not been characterized. METHODS: Sera from 308 infertile women were investigated for antibodies to M. genitalium by immunoblotting. Women with tubal factor infertility (TFI) made up 132 of the patients, 67 of the women had an infertile male partner and 109 were infertile for unknown reasons. RESULTS: Of the TFI patients 29 (22.0%) were seropositive to the major adhesin, MgPa, of M. genitalium versus 11 (6.3%) in the group of women with normal tubes. No cross-reactions between MgPa and P1 of the related Mycoplasma pneumoniae were found. Besides, MgPa positive sera were confirmed by immunoblotting using a cloned fragment of the C-terminal part of MgPa specific to M. genitalium. Chlamydia trachomatis is known to be able to cause infertility as a result of salpingitis. Therefore, the sera were tested against C. trachomatis using a commercial ELISA test. Seventy-five (56.8%) of the TFI patients were seropositive to C. trachomatis. Eight (27.6%) TFI patients seropositive to MgPa were negative to C. trachomatis. CONCLUSIONS: This study indicates that M. genitalium may be an independent risk factor in the development of an inflammatory process leading to scarring of the uterine tubes in women and thereby causing infertility.

Key words: Chlamydia trachomatis/infertility/MgPa/Mycoplasma genitalium/salpingitis

6 To whom correspondence should be addressed at: Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark. E-mail: hellef{at}biobase.dk


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