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Human Reproduction, Vol. 17, No. 1, 219-220, January 2002
© 2002 European Society of Human Reproduction and Embryology

Interleukin-2 receptor concentrations in pregnant women with a history of recurrent miscarriage

M.A. MacLean1, R. Wilson1,3, C. Jenkins1, H. Miller1 and J.J. Walker2

1 Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland and 2 Department of Obstetrics and Gynaecology, St James Hospital, Leeds, UK

BACKGROUND: The mechanism by which the maternal immune system tolerates the fetus during pregnancy is unclear. METHODS: This study measured interleukin-2 receptor (IL-2R) concentrations in the serum of non-pregnant women (Group 1); healthy first trimester pregnant women (Group 2); pregnant women with a history of recurrent miscarriage whose pregnancies again failed later in the first trimester (Group 3); and first trimester pregnant women with a history of recurrent miscarriage but whose pregnancies on this occasion went successfully to term (Group 4). An initial sample was obtained from all women in Groups 1, 2, 3 and 4. A further sample was obtained 4 weeks later from women in Groups 1, 2 and 4. RESULTS: The initial sample showed no significant difference in IL-2R concentrations between Groups 1 and 2. Concentrations were significantly higher in Groups 3 (667 ± 244 U/ml; P < 0.003) and 4 (730 ± 360 U/ml; P < 0.05) compared with healthy pregnant women (425 ± 94). When the second sample was obtained concentrations in Group 4 were found to have fallen so that they no longer differed from Group 2. CONCLUSIONS: Our results confirm earlier findings that a successful pregnancy is associated with significantly lower concentrations of IL-2R.

Key words: pregnancy/miscarriage/IL-2R

3 To whom correspondence should be addressed at: Department of Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK. E-mail: gcl025{at}clinmed.gla.ac.uk


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