Human Reproduction, Vol. 17, No. 1, 233-246,
January 2002
© 2002 European Society of Human Reproduction and Embryology
ESHRE Preimplantation Genetic Diagnosis Consortium: data collection III (May 2001)
The ESHRE PGD Consortium was formed in 1997 to undertake a long-term study of the efficacy and clinical outcome of preimplantation genetic diagnosis (PGD). Here, the third report of the ESHRE PGD Consortium is presented, collating data received from 25 centres on referrals, cycles, pregnancies and babies born after PGD. The second report, published in December 2000, reported on 886 referrals, a total of 1318 started cycles (of which 465 for aneuploidy screening, 386 for fluorescence in-situ hybridization (FISH) and 385 for PCR going beyond oocyte retrieval), 163 pregnancies and 162 children born. This year, 675 referrals from 12 centres were added giving a total of 1561 referrals, 370 regular PGD cycles, 334 PGD-aneuploidy screening (PGD-AS) cycles and 78 cycles for social sexing from 24 centres and 215 pregnancies and 117 babies from 12 centres. Because more in-depth information was asked for the cycles, this year's data will be shown separately as well as cumulatively. One striking feature of this year's data collection is the appearance of the first data for gender screening on preimplantation embryos for social reasons. The ethical concerns regarding social sexing will be discussed, as well as the forthcoming changes in timing of data collection. When the data collection was discussed at the last meeting of the members of the ESHRE PGD Consortium in Lausanne, Switzerland (June, 2001), it appeared that the current system of data collection, although yielding results very quickly, showed fundamental flaws. The ESHRE PGD Consortium Steering Committee intends to remedy to these problems, on the one hand by introducing a new type and timing of data collection, and on the other hand by re-analysing and correcting the data which have already been sent in during the past 4 years.
Key words: Consortium data collection/FISH/gender screening/PCR/PDG
* The ESHRE PGD Consortium Steering Committee: Karen Sermon1 (chairperson), Centre for Medical Genetics, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium, E-mail lgensnk{at}az.vub.ac.be Joyce Harper (deputy-chair), Department of Obstetrics and Gynaecology, University College London, 86–96 Chenies Mews, London WC1E 6HX, UK, E-mail joyce.harper{at}ucl.ac.uk Joep Geraedts (deputy-chair), Department of Molecular Cell Biology and Genetics, University of Maastricht, J. Bechlaan, 113, Maastricht, The Netherlands, E-mail joep.geraedts{at}gen.unimaas.nl Christine de Die-Smulders, Department of Molecular Cell Biology and Genetics, University of Maastricht, J. Bechlaan, 113, Maastricht, The Netherlands, E-mail christine.dedie{at}gen. unimaas.nl Alan Handyside School of Biology, University of Leeds, Leeds, UK, E-mail; A.H.Handyside{at}bmb.leeds.ac.uk Nicole Hussey, Dept. of Ob/Gyn, University of Adelaide, E-mail Nicole.Hussey{at}adelaide.edu.au Maria-Christina Magli, SISMER, Via Mazzini, 12, 40137 Bologna, Italy, E-mail cristina.magli{at}sismer.it Santiago Munné, Institute of Reproductive Medicine and Science, Saint Barnabas Medical Centre, 101 Old Short Hills Road, Suite 501, West Orange, New Jersey 07052 USA, E-mail santi.munne{at}embryos.net Pierre Ray, Département de Génétique, Hopital Necker Enfants Malades, 75743 Paris Cedex 15, France, E-mail ray{at}necker.fr Josep Santalo, Unitat de Biologia Cel.lular, Univ. Autonoma, Barcelona, E-mail Josep.santalo{at}uab.es Catherine Staessen, Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium, E-mail lriasnc{at}az.vub.ac.be Alan Thornhill, Division of Reproductive Endocrinology and Infertility, Mayo Clinic, 200 First Street SW, Rochester MN 55905, E-mail Thornhill.Alan{at}mayo.edu Stéphane Viville, BP63, IGBMC, 1, Rue Laurent Fries, 67404 Illkirch-Strassbourg, France, E-mail viville{at}titus.u-strasbg.fr Leeanda Wilton, Melbourne IVF, 320 Victoria Parade, 3002 East Melbourne VIC, Australia, E-mail Lwilton{at}mivf.com.au.
1 To whom correspondence should be addressed at: Centre for Medical Genetics, Dutch-speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium. E-mail lgensnk{at}az.vub.ac.be.
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