Human Reproduction, Vol. 17, No. 10, 2495-2499,
October 2002
© 2002 European Society of Human Reproduction and Embryology
Debate continued |
What is polycystic ovarian syndrome?
A proposal for a consensus on the definition and diagnosis of polycystic ovarian syndrome
Lis Maternity Hospital, Tel Aviv (Sourasky) Medical Centre, 6 Weizmann Street, Tel Aviv 64239, Israel. (Affiliated to Sackler Medical School, Tel Aviv University). E-mail: homburg{at}netvision.net.il
The criteria for diagnosis and definition of polycystic ovarian syndrome used by clinicians and investigators are almost as heterogeneous as the syndrome itself. This has confused and seriously hindered the clarification of the genetics, aetiology, clinical associations and assessment of treatment and later sequelae of the syndrome. This article proposes a consensus for a unifying balanced and practical working definition for use as a standard. The proposal incorporates confirmation of the diagnosis suggested by clinical symptoms by ultrasound, and the use of hormonal estimations if typical ultrasound features are not seen and for the purpose of defining subsets of the syndrome. This consensus proposal attempts to bridge the gap between predominately American biochemical marker-based diagnosis and predominately European reliance on ultrasound as a sine qua non for diagnosis. It has been deliberately designed to be simple, practical and cheap, and if universally adopted as a standard could contribute much to all future work involving this most prevalent of syndromes.
Key words: consensus/definition/diagnosis/polycystic ovarian syndrome/ultrasound
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G.L. Jones, J.M. Hall, A.H. Balen, and W.L. Ledger Health-related quality of life measurement in women with polycystic ovary syndrome: a systematic review Hum. Reprod. Update, January 1, 2008; 14(1): 15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferk, N. Teran, and K. Gersak The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome Hum. Reprod., April 1, 2007; 22(4): 1031 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Belosi, L. Selvaggi, R. Apa, M. Guido, D. Romualdi, A.M. Fulghesu, and A. Lanzone Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma? Hum. Reprod., December 1, 2006; 21(12): 3108 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Moll, P. M M Bossuyt, J. C Korevaar, C. B Lambalk, and F. van der Veen Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial BMJ, June 24, 2006; 332(7556): 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez, M.E. Saez, M.J. Aragon, J.J. Galan, P. Vettori, L. Molina, C. Rubio, L.M. Real, A. Ruiz, and R. Ramirez-Lorca Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome Hum. Reprod., April 1, 2006; 21(4): 943 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Bokal, H. M. Vrtovec, I. V. Klun, and I. Verdenik Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome Hum. Reprod., June 1, 2005; 20(6): 1562 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Kilicdag, T. Bagis, E. Tarim, E. Aslan, S. Erkanli, E. Simsek, B. Haydardedeoglu, and E. Kuscu Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial Hum. Reprod., June 1, 2005; 20(6): 1521 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Escobar-Morreale, M. Luque-Ramirez, and J. L. San Millan The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome Endocr. Rev., April 1, 2005; 26(2): 251 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J R Porter and T G Barrett Acquired non-type 1 diabetes in childhood: subtypes, diagnosis, and management Arch. Dis. Child., December 1, 2004; 89(12): 1138 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guido, D. Romualdi, R. Suriano, M. Giuliani, B. Costantini, R. Apa, and A. Lanzone Effect of pioglitazone treatment on the adrenal androgen response to corticotrophin in obese patients with polycystic ovary syndrome Hum. Reprod., March 1, 2004; 19(3): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Sheehan Polycystic Ovarian Syndrome: Diagnosis and Management Clin. Med. Res., February 1, 2004; 2(1): 13 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bayram, M. van Wely, E. M Kaaijk, P. M M Bossuyt, and F. van der Veen Using an electrocautery strategy or recombinant follicle stimulating hormone to induce ovulation in polycystic ovary syndrome: randomised controlled trial BMJ, January 24, 2004; 328(7433): 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gonzalez, E. Abril, A. Roca, M. J. Aragon, M. J. Figueroa, P. Velarde, R. Ruiz, O. Fayez, J. J. Galan, J. A. Herreros, et al. Specific CAPN10 Gene Haplotypes Influence the Clinical Profile of Polycystic Ovary Patients J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5529 - 5536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Orvieto and Z. Ben-Rafael Polycystic ovary syndrome: a simplified approach based on the evolving set of symptoms Hum. Reprod., April 1, 2003; 18(4): 896 - 897. [Full Text] [PDF]
|
|