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Human Reproduction, Vol. 17, No. 10, 2560-2563, October 2002
© 2002 European Society of Human Reproduction and Embryology

Triple-Y syndrome following ICSI treatment in a couple with normal chromosomes

Case report

Geetha Venkataraman and Ian Craft1

London Fertility Centre, Cozens House, 112a Harley Street, London W1G 7JH, UK

We report the case of 48,XYYY in a fetus resulting from ICSI treatment in a chromosomally normal couple. A 35 year old couple underwent an ICSI treatment resulting in a maintained clinical pregnancy. Amniocentesis at 13 weeks identified the Triple-Y syndrome in the fetus. Both the parents had normal karyotypes (46,XX and 46,XY). The pregnancy was terminated at 18 weeks and fetal tissue culture confirmed the 48,XYYY syndrome. This is the first reported case of the Triple-Y syndrome following ICSI treatment in a chromosomally normal couple.

Key words: chromosomal anomalies/ICSI treatment

1 To whom correspondence should be addressed. E-mail: info{at}lfc.org.uk


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