Human Reproduction, Vol. 17, No. 10, 2636-2640,
October 2002
© 2002 European Society of Human Reproduction and Embryology
Factors influencing the obstetric and perinatal outcome after oocyte donation
1 Departments of Obstetrics and Gynecology, The Lis Maternity Hospital, 6 Weizman St, Tel Aviv 46427, 2 The Sheba Medical Center, Tel-Hashomer and 3 Wolfson hospital, Holon and The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel
BACKGROUND: We evaluated interactions between perinatal outcome after oocyte donation and various maternal factors. METHODS: The study included 134 parturients after oocyte donation. Data were collected from medical files and personal interviews. Stepwise logistic regression analyses were used to evaluate associations between perinatal outcomes and selected maternal variables. RESULTS: Fifty percent of the women were >43 years old, 30.6% were >45 years and 67.9% were nulliparous. The rates of pregnancy induced hypertension (PIH), gestational diabetes and first and second trimester vaginal bleeding (STB) were 27.6, 23.9, 43.3 and 6% respectively, while 72% had Caesarean deliveries. The rates of preterm (PD), low birth weight (LBW), small for gestational age (SGA) deliveries and major malformations were respectively 14.9, 14.9, 7.6 and 2.2%. Using a logistic regression, PD was significantly associated with PIH, STB and maternal smoking. LBW deliveries were significantly associated with PIH, STB, nulliparity and maternal smoking. SGA babies were significantly associated with PIH. These perinatal outcomes were not associated with advanced maternal age or ovarian failure. CONCLUSIONS: There is a high risk of obstetric complications in singleton oocyte donation pregnancies, but the perinatal outcomes are favourable. Patients should be counselled about these risks and monitored for these complications during pregnancy.
Key words: first and second trimester bleeding/gestational diabetes mellitus/hypertensive disorders in pregnancy/oocyte donation/perinatal outcome
4 To whom correspondence should be addressed. E-mail: smgalit{at}hotmail.com
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