Human Reproduction, Vol. 17, No. 10, 2737-2741,
October 2002
© 2002 European Society of Human Reproduction and Embryology
Clinical outcomes following percutaneous magnetic resonance image guided laser ablation of symptomatic uterine fibroids
1 Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary’s Hospital, London, UK, 2 University of Western Australia, Women and Infants Research Foundation, Department of Obstetrics and Gynaecology, Subiaco WA 6008, Australia, 3 Health Services Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK and 4 Department of Interventional Magnetic Resonance Imaging, St Mary’s Hospital, London, UK
BACKGROUND: Fibroids are common benign tumours of the uterus. Percutaneous magnetic resonance (MR) image guided laser ablation provides a minimally invasive, day-case alternative to surgery for the treatment of symptomatic fibroids. METHODS: Women with symptomatic fibroids wishing to avoid surgery were treated with laser ablation. MR thermal mapping ensured that maximal safe energy was applied. Fibroid volume was measured at 3 and 12 months, menstrual blood loss was recorded before and after treatment and a menorrhagia outcomes questionnaire (MOQ) was used to assess satisfaction. RESULTS: A total of 66 patients was treated. There was a significant (P < 0.001) reduction in mean fibroid volume of 31%. This was 41% at 1 year follow-up (P < 0.001). Measured menstrual blood loss in eight patients complaining of excessive bleeding was reduced (P = 0.012). The MOQ total outcome score was not as good as that seen in hysterectomy patients (P = 0.02) but the quality of life/satisfaction score was similar (P = 0.06). CONCLUSION: We have used objective and subjective outcome measures to determine the efficacy of MR guided laser ablation for fibroids. Based on this limited study we are encouraged that this procedure may represent a minimally invasive alternative therapy for fibroids.
Key words: fibroid/laser/MRI/outcomes/treatments
5 To whom correspondence should be addressed at: Interventional MRI, Clarence Wing, St Mary’s Hospital, London W2 1NY, UK. E-mail: w.gedroyc{at}ic.ac.uk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Recaldini, G. Carrafiello, D. Lagana, S. Cuffari, V. Bergamini, F. Ghezzi, and C. Fugazzola Percutaneous Sonographically Guided Radiofrequency Ablation of Medium-Sized Fibroids: Feasibility Study Am. J. Roentgenol., December 1, 2007; 189(6): 1303 - 1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hindley, W. M. Gedroyc, L. Regan, E. Stewart, C. Tempany, K. Hynnen, N. Macdanold, Y. Inbar, Y. Itzchak, J. Rabinovici, et al. MRI Guidance of Focused Ultrasound Therapy of Uterine Fibroids: Early Results Am. J. Roentgenol., December 1, 2004; 183(6): 1713 - 1719. [Abstract] [Full Text] [PDF]
|
|