Human Reproduction, Vol. 17, No. 10, 2777,
October 2002
© 2002 European Society of Human Reproduction and Embryology
Sublingual misoprostol for first trimester termination of pregnancy: safety concerns
1 Department of Obstetrics and Gynaecology, National University of Singapore, Singapore 119074 and 2 Department of Obstetrics and Gynaecology, St Georges Hospital Medical School, London SW17 0RE, UK.
| The first 10% of the full text of this article appears below. |
| Introduction |
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Dear Sir,
We read with interest the study by Tang and colleagues on the pharmacokinetics of misoprostol administered by various routes for first trimester abortion (Tang et al., 2002a
). The authors reported that the sublingual and oral routes resulted in significantly higher serum peak concentrations of misoprostol acid compared with the vaginal route, with significantly shorter times to