Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Stadtmauer, L. A.
Right arrow Articles by Oehninger, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stadtmauer, L. A.
Right arrow Articles by Oehninger, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 17, No. 12, 3016-3026, December 2002
© 2002 European Society of Human Reproduction and Embryology

Debate continued

Should patients with polycystic ovary syndrome be treated with metformin?

Benefits of insulin sensitizing drugs in polycystic ovary syndrome—beyond ovulation induction

Laurel A. Stadtmauer1, Benjamin C. Wong and Sergio Oehninger

The Howard and Georgeanna Jones Institute for Reproductive Medicine, 601 Colley Avenue, Norfolk, VA 23507, USA

The debate on metformin use in polycystic ovary syndrome (PCOS) has mainly focused on its treatment for infertility in ovulation induction and menstrual cyclicity. Here we will summarize the data supporting the effect of metformin on improving hyperandrogenaemia and hyperinsulinaemia in PCOS patients. We propose that metformin benefits PCOS patients undergoing gonadotrophin therapy and IVF as well as ovulation induction. We also advocate the use of insulin sensitizing drugs to reduce miscarriage rates, and risks associated with coronary artery disease, gestational diabetes and obesity.

Key words: hyperandrogenism/insulin resistance/metformin/polycystic ovary syndrome

1 To whom correspondence should be addressed. E-mail: stadtmla{at}evms.edu


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
G. Onalan, B. Selam, Y. Baran, M. Cincik, R. Onalan, U. Gunduz, A. U. Ural, and R. Pabuccu
Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF
Hum. Reprod., September 1, 2005; 20(9): 2391 - 2395.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. B. Kilicdag, T. Bagis, E. Tarim, E. Aslan, S. Erkanli, E. Simsek, B. Haydardedeoglu, and E. Kuscu
Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial
Hum. Reprod., June 1, 2005; 20(6): 1521 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. B. Kilicdag, T. Bagis, H. B. Zeyneloglu, E. Tarim, E. Aslan, B. Haydardedeoglu, and S. Erkanli
Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study
Hum. Reprod., April 1, 2005; 20(4): 894 - 899.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.J. Glueck, N. Goldenberg, J. Pranikoff, M. Loftspring, L. Sieve, and P. Wang
Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy
Hum. Reprod., June 1, 2004; 19(6): 1323 - 1330.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
N. Boulman, Y. Levy, R. Leiba, S. Shachar, R. Linn, O. Zinder, and Z. Blumenfeld
Increased C-Reactive Protein Levels in the Polycystic Ovary Syndrome: A Marker of Cardiovascular Disease
J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2160 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. M Lord, I. H K Flight, and R. J Norman
Metformin in polycystic ovary syndrome: systematic review and meta-analysis
BMJ, October 25, 2003; 327(7421): 951.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.