Human Reproduction, Vol. 17, No. 2, 304-309,
February 2002
© 2002 European Society of Human Reproduction and Embryology
Delivery rates following IVF treatment, using two recombinant FSH preparations for ovarian stimulation
Reproductive Medical Centre, Department of Women and Child Health, Division of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden
BACKGROUND: A prospective, semi-randomized, open, clinical study was conducted to compare ovarian response, pregnancy outcome and delivery rates using two recombinant FSH preparations (Gonal-F® and Puregon®) for IVF. METHODS: We analysed stimulation parameters and outcome data in 812 initiated treatment cycles where 292 women used Gonal-F and 200 used Puregon. Embryo transfer was carried out in 676 cycles. In the two preparation groups we also compared 170 women previously treated with FSH for IVF with 266 previously untreated. RESULTS: The pregnancy rate with Gonal-F was 26% and with Puregon 28%. Delivery rates were identical, 22%. Clinical pregnancy and delivery rates per cycle with embryo transfer in earlier untreated women were 29.0 and 24.0%, whereas in previously treated women they were 23.5 and 18.8% respectively. After repeated cycles, delivery frequencies consecutively decreased, independent of the FSH preparation used. CONCLUSION: Gonal-F and Puregon seem to be equally potent in achieving follicular development and equally effective, in terms of delivery rates, for use in an IVF programme. Repeated cycles resulted in equally large consecutive decreases in delivery rates, regardless of preparation choice, but were considered worthwhile for up to three stimulation cycles in selected patients.
Key words: delivery rates/ovarian stimulation/recombinant FSH
1 To whom correspondence should be addressed at: Department of Women and Child Health, Division of Obstetrics and Gynaecology, Karolinska Hospital, S-171 76 Stockholm, Sweden. E-mail: jonas.harlin{at}ks.se
Submitted on April 17, 2001; resubmitted on September 10, 2001
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