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Human Reproduction, Vol. 17, No. 3, 534-538, March 2002
© 2002 European Society of Human Reproduction and Embryology

Opinions

Ethical considerations on preimplantation genetic diagnosis for HLA typing to match a future child as a donor of haematopoietic stem cells to a sibling

G. Pennings1,4, R. Schots2 and I. Liebaers3

1 Department of Philosophy, 2 Department of Medical Oncology and Hematology and 3 Center for Medical Genetics, Academic Hospital, Free University Brussels

Abstract

Recently, several requests were made by couples with an affected child who wanted preimplantation genetic diagnosis (PGD) to select embryos in the hope of conceiving an HLA identical donor sibling. This article considers the ethical arguments for and against the application of PGD for this goal. Only embryos HLA matched with an existing sibling in need of a compatible donor of haematopoietic stem cells would be transferred. The main arguments are the instrumentalization of the child, the best-interests standard, the postnatal test for acceptability and the experience of the donor child. It is argued that conceiving a child to save a child is a morally defensible decision on the condition that the operation that will be performed on the future child is acceptable to perform on an existing child. The instrumentalization of the donor child does not demonstrate disrespect for its autonomy or its intrinsic worth.

Key words: ethics/haematopoietic stem cells/HLA matching/preimplantation genetic diagnosis/transplantation

Notes

4 To whom correspondence should be addressed: Department of Philosophy, Lok. 5 C 442, Free University Brussels, Pleinlaan 2,B-1050 Brussels, Belgium. E-mail: gpenning{at}vub.ac.be


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