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Human Reproduction, Vol. 17, No. 3, 695-698, March 2002
© 2002 European Society of Human Reproduction and Embryology

The value of Chlamydia trachomatis antibody testing in predicting tubal factor infertility

L.M.W. Veenemans1 and P.J.Q. van der Linden1,2

1 Department of Obstetrics and Gynaecology, Deventer Ziekenhuis

BACKGROUND: The objective of the present study was to compare the likelihood of abnormal Chlamydia trachomatis antibody test results with that of abnormal hysterosalpingography (HSG) test results in patients with tubal factor infertility. METHODS: Anti-C. trachomatis immunoglobulin G antibodies were determined prospectively in 295 infertility patients by means of an indirect fluorescent antibody technique. In 48 of the 295 patients both HSG and laparoscopy with chromotubation were performed. The results of C. trachomatis antibody testing were compared with the results of HSG with respect to their predictive value of tubal factor infertility. Likelihood ratios for abnormal C. trachomatis antibody and HSG test results were determined in infertility patients, as assessed by laparoscopy. RESULTS: The positive likelihood ratio for C. trachomatis antibody testing was 1.8. This was comparable with the HSG, which had a positive likelihood ratio of 1.7. CONCLUSIONS: The predictive value of C. trachomatis antibody testing was equal to that of HSG, but ratios of 1.7 and 1.8 indicate a poor test, so both C. trachomatis antibody testing and HSG have a poor predictive value. C. trachomatis antibody testing causes minimal inconvenience to the patient, in contrast to HSG, and therefore should be maintained in infertility examinations.

Key words: Chlamydia trachomatis testing/likelihood ratios/receiver operating curve/tubal infertility

2 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Deventer Ziekenhuis, P.O. Box 5002, 7400 GC Deventer, The Netherlands. E-mail: lindevdp{at}dz.nl

Submitted on 8 December 2000; resubmitted on August 13, 2001


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