Human Reproduction, Vol. 17, No. 3, 736-740,
March 2002
© 2002 European Society of Human Reproduction and Embryology
Relationship between time period after vasectomy and the reproductive capacity of sperm obtained by epididymal aspiration
1 Clínica e Centro de Pesquisa em Reproducião Humana Roger Abdelmassih, São Paulo, Brasil and 2 Mar&Gen, Granada, Spain
BACKGROUND: It is not well defined whether the elapsed time after vasectomy has any influence on the outcome of IVF–ICSI using epididymal sperm. We analysed retrospectively the results of 151 ICSI cycles in which sperm of vasectomized men were used at different time periods after vasectomy. METHODS: Oocytes were obtained after a desensitizing ovarian stimulation protocol using GnRH agonist in association with recombinant FSH and HCG. Sperm were retrieved by percutaneous epididymal sperm aspiration. The cycles were split into three groups: 
10 years after vasectomy (group 1, n = 47), 11–19 years after vasectomy (group 2, n = 79), and 
20 years after vasectomy (group 3, n = 25). RESULTS: As might be expected, the mean age of men differed in the three groups (group 3 > group 2 > group 1), and the mean age of the women was also significantly higher in group 3 than in groups 1 and 2, although no differences were described between groups 2 and 3. All other laboratory and clinical parameters were similar in the three groups. Ongoing pregnancy and implantation rates (34, 25, 8% and 22, 15, 6% respectively) decreased significantly from group 1 to group 3. CONCLUSION: Pregnancy and implantation rates after ICSI with sperm from vasectomized men are negatively correlated with the time interval from vasectomy, which cannot be explained purely by male or female ageing.
Key words: epididymal sperm/implantation rate/pregnancy rate/time from vasectomy
3 To whom correspondence should be addressed at: Clínica e Centro de Pesquisa em Reproducião Humana Roger Abdelmassih, Rua Maestro Elias Lobo, 805, Jardim Paulista, Cep: 01433–000, São Paulo SP, Brazil. E-mail: drpeter{at}dglnet.com.br
Submitted on September 21, 2001
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