Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Strandell, A.
Right arrow Articles by Lindhard, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strandell, A.
Right arrow Articles by Lindhard, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 17, No. 5, 1141-1145, May 2002
© 2002 European Society of Human Reproduction and Embryology

Why does hydrosalpinx reduce fertility?

The importance of hydrosalpinx fluid

Annika Strandell1,3 and Anette Lindhard2

1 Reproductive Medicine, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, S-413 45, Göteborg, Sweden and 2 The Fertility Clinic, Copenhagen University hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

The debate on hydrosalpinx and impaired IVF outcome has mainly focused on the best treatment before IVF and on functional surgery as an alternative treatment. We would like to initiate a debate on the possible reasons why the outcome is impaired. We know that salpingectomy is effective in terms of improved birth rates after IVF, but we do not know exactly why. The main focus is on embryotoxic properties of the hydrosalpinx fluid, which include micro-organisms, endotoxins, cytokines, oxidative stress and lack of nutrients. The endometrial receptivity may be reduced as an effect of disturbed expression of the cytokine cascade, which is essential for implantation. The presence of excessive fluid in the uterine cavity may also be a mechanical hindrance to implantation. We believe that the hydrosalpinx fluid is of crucial importance, but the actual mechanism of action needs to be clarified.

Key words: embryotoxicity/hydrosalpinx/IVF outcome/salpingectomy

3 To whom correspondence should be addressed. E-mail: annika.strandell{at}medfak.gu.se


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
E. H. Ruder, T. J. Hartman, J. Blumberg, and M. B. Goldman
Oxidative stress and antioxidants: exposure and impact on female fertility
Hum. Reprod. Update, June 4, 2008; (2008) dmn011v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. Palomba, F. Orio Jr., A. Falbo, T. Russo, A. Tolino, and F. Zullo
Clomiphene Citrate Versus Metformin as First-Line Approach for the Treatment of Anovulation in Infertile Patients with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3498 - 3503.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
P. M. Lam, C. Briton-Jones, C. K. Cheung, L. S. Po, L. P. Cheung, and C. Haines
Increased mRNA expression of vascular endothelial growth factor and its receptor (flt-1) in the hydrosalpinx
Hum. Reprod., November 1, 2003; 18(11): 2264 - 2269.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.