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Human Reproduction, Vol. 17, No. 6, 1468-1471, June 2002
© 2002 European Society of Human Reproduction and Embryology

An unusual steroid-producing ovarian tumour: Case report

J.W. Stephens1,5, J.R. Katz2, N. McDermott3, A.B. MacLean4 and P-M.G. Bouloux2

1 Department of Diabetes and Endocrinology, University College Hospitals, Mortimer Street, London W1N 8AA, 2 Centre for Neuroendocrinology, Royal Free and University College Medical School, Pond Street, London NW3 2QG, 3 Department of Histopathology, Royal Free Hospital, Pond Street, London NW3 2QG and 4 University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK

The rapid onset of virilization in a post-menopausal woman is usually the result of androgen secretion from a tumour of adrenal or ovarian origin. Androgen secreting neoplasms of the ovary are rare and usually show autonomous secretion. Rarely, these may be driven by the high levels of gonadotrophins seen in the post-menopausal state. We describe the case of a 67-year-old woman with high serum testosterone and estradiol in association with the high gonadotrophin levels usually associated with the post-menopausal state. All hormonal parameters showed a significant suppression over 12 h with administration of the GnRH antagonist, cetrorelix. This observation implies that excess hormone synthesis was of ovarian origin and was gonadotrophin driven. Localization of the tumour was not possible by conventional ultrasound or computerized tomography scanning, but was achieved by venous sampling. Complete cure was achieved by total abdominal hysterectomy and bilateral salpingo-oophorectomy, with restoration of the endocrine profile to that expected for a post-menopausal woman. Rapidly acting GnRH antagonists, such as cetrorelix, offer a safe and useful diagnostic and therapeutic option in the management of ovarian steroid-secreting tumours, which show gonadotrophin dependency.

Key words: cetrorelix/GnRH antagonist/hyperandrogenaemia/ovarian tumour/virilization

5 To whom correspondence should be addressed. E-mail: jwstephens{at}tinyworld.co.uk


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 Eur J EndocrinolHome page
H. de Boer, M. de Man, K. de Bruyn, and A. van Sorge
Cetrorelix suppression test to assess the source of androgen overproduction in postmenopausal hirsutism
Eur. J. Endocrinol., September 1, 2006; 155(3): 391 - 393.
[Abstract] [Full Text] [PDF]


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