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Human Reproduction, Vol. 17, No. 6, 1525-1531, June 2002
© 2002 European Society of Human Reproduction and Embryology

Cohort follow-up of couples with primary infertility in an ART programme using frozen donor semen

Fabrice Guerif1, Florence Fourquet2, Henri Marret1, Marie-Helene Saussereau1, Claire Barthelemy1, Claire Lecomte1, Pierre Lecomte1, Jacques Lansac1 and Dominique Royere1,3

1 CECOS, Biologie de la Reproduction, Département de Gynécologie-Obstétrique et Reproduction Humaine, Centre Hospitalier Universitaire Bretonneau, 37044 Tours, and 2 Service d'Information Médicale et d'Hygiène, Centre Hospitalier Universitaire Bretonneau, 37044 Tours, France

BACKGROUND: This study was designed to determine the crude cumulative live-birth rates in a cohort initiating frozen donor semen treatment until completion. METHODS: This cohort study included 588 couples with primary infertility in one University Hospital centre. The treatment sequence involved first artificial insemination (AID) followed by IVF if necessary (IVF-D). Live birth, drop-out for personal or medical reasons and recourse to IVF-D were recorded for all patients. Live births and drop-out were expressed both as rates per cycle and crude cumulative rates. RESULTS: At the completion of AID and IVF-D cycles, 406 couples in the cohort (69%) achieved a live-birth and 182 couples (31%) discontinued treatment. In most cases, couples stopped treatment for personal reasons (74%) whereas fewer couples were denied further treatment for medical reasons (26%). CONCLUSIONS: This is the first report on the crude cumulative live-birth rate in a cohort after AID and IVF-D cycles. Although calculation based on crude cumulative live-birth rate shows lower results in comparison with life table analysis, this method allows patients to obtain an insight into their actual chances of achieving a successful pregnancy.

Key words: artificial insemination/crude cumulative live-birth rate/drop-out/frozen donor semen/IVF

3 E-mail: royere{at}med.univ-tours.fr


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F. Guerif, M.H. Saussereau, C. Barthelemy, M. Lanoue, C. Lecomte, V. Ract, J. Lansac, and D. Royere
Achievement of second parenthood in an ART programme using frozen donor semen: cohort follow-up
Hum. Reprod., September 1, 2003; 18(9): 1853 - 1857.
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