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Human Reproduction, Vol. 17, No. 7, 1833-1836, July 2002
© 2002 European Society of Human Reproduction and Embryology

Achievement of pregnancy in globozoospermia with Y chromosome microdeletion after ICSI: Case report

Hulusi Bulent Zeyneloglu1,4, Volkan Baltaci2, Hakan Eyup Duran1, Esra Erdemli3 and Sertac Batioglu1

1 Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, 2 Medical Genetics, Faculty of Medicine, Baskent University Kubilay Sok, 36 Maktepo, Ankara 06570 and 3 Department of Histology and Embryology, Faculty of Medicine, Ankara University, Shihhye Ankara 06100, Turkey

Pregnancy achieved with sperm from a patient with globozoospermia is rare, even after ICSI, since the activation of the oocyte may not occur in this disorder. Therefore, activation of the oocytes by piezoelectricity or calcium ionophores has been suggested, although spontaneous activation of the oocyte after ICSI has been reported in some cases. We report a successful pregnancy in a couple in which the male partner had globozoospermia with microdeletions in the Y chromosome with no further assisted activation after ICSI. During the diagnostic study of the husband, increased numerical chromosome abnormalities after fluorescent in-situ hybridization (FISH) and microdeletions in AZFa; sY86 and AZFb; sY 131 were detected. Out of the 13 oocytes injected, four fertilized and a twin pregnancy was obtained after replacement of four embryos. Healthy twin girls were delivered after a term pregnancy. Some patients with globozoospermia may also have Y chromosome microdeletions, which subsequently may be inherited by the male offspring in cases of achievement of pregnancy.

Key words: globozoospermia/ICSI/infertility/microdeletion

4 To whom correspondence should be addressed at: Mesa Koru Sitesi Manolya Blok 24, Cayyolu, Ankara, 06530 Turkey. E-mail: hnzeynelog{at}e-kolay.net


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