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Human Reproduction, Vol. 18, No. 11, 2309-2314, November 2003
© 2003 European Society of Human Reproduction and Embryology

Interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) gene polymorphisms are not associated with tubal pathology and Chlamydia trachomatis-related tubal factor subfertility

Laura S. Murillo1, Jolande A. Land2, Jolein Pleijster1, Cathrien A. Bruggeman3, A. Salvador Peña1 and Servaas A. Morré1,4

1 Laboratory of Immunogenetics, VU University Medical Centrum, Van der Boechorststraat 7, 1081 BT Amsterdam, 2 Research Institute of Growth and Development (GROW) and Department of Obstetrics and Gynaecology, and 3 Department of Medical Microbiology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht The Netherlands

4 To whom correspondence should be addressed. e-mail: samorre{at}hotmail.com

BACKGROUND: Chlamydia trachomatis infections have been associated with tubal pathology. However, not all C.trachomatis-infected women actually develop tubal pathology. Recently, host genetic factors such as the interleukin-1 gene cluster have been linked to inflammatory and infectious diseases. METHODS: Dutch Caucasian women were investigated for (i) the role of interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) gene polymorphisms in tubal pathology (group 1); and (ii) the presence of these gene polymorphisms in C.trachomatis IgG-positive women with and without tubal pathology (group 2). Group 1 consisted of women with (n = 40) or without (n = 95) tubal pathology, respectively, and group 2 of C.trachomatis IgG-positive women of whom 28 had tubal pathology at laparoscopy and 47 did not. IL-1B-511 and IL-1B+3954 gene polymorphisms were assessed by PCR–restriction fragment length polymorphism (RFLP), and the variable number of tandem repeats (VNTR) of the IL-1RN gene were assessed by a PCR-based assay. RESULTS: Neither IL-1B-511, IL-1B+3954 nor IL-1RN genotypes, allele or carrier frequencies showed significant association with tubal pathology or C.trachomatis post-infection-based tubal pathology. CONCLUSIONS: The data obtained suggest that specific IL-1 gene polymorphisms are not associated with the tubal pathology risk or to the development of C.trachomatis-based post-infectious severe sequelae.

Key words: Chlamydia trachomatis/immunogenetics/interleukin-1B (IL-1B) gene/interleukin-1 receptor antagonist (IL-1RN) gene/tubal pathology


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[Abstract] [Full Text] [PDF]


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