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Human Reproduction, Vol. 18, No. 11, 2375-2381, November 2003
© 2003 European Society of Human Reproduction and Embryology

Thromboembolism after ovarian stimulation: successful management of a woman with superior sagittal sinus thrombosis after IVF and embryo transfer: Case report

Yu-Che Ou1, Yeh-Lin Kao2, Shung-Lon Lai3, Fu-Tsai Kung1,4, Fu-Jen Huang1, Shiuh-Young Chang1 and Chan-Chao ChangChien1

1 Department of Obstetrics and Gynecology, 2 Department of Radiology and 3 Department of Neurology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung County, Taiwan. e-mail: ftkung{at}ksts.seed.net.tw

The current literature was reviewed in order to analyse the clinical manifestations, progression and management, and pregnancy outcome of thromboembolism in infertile patients undergoing ovarian stimulation. The first case of superior sagittal sinus thrombosis following IVF that was successfully managed with intracranial thrombectomy is also reported. This retrospective cohort study comprised 65 women who experienced thromboembolism after ovarian stimulation (64 from other published studies and the present case report). Thrombosis attack occurred at a mean (±SD) of 25.5 ± 20.1 days after oocyte retrieval. The onset timing in the intracranial thrombosis group (10.2 ± 4.6 days) was less (P < 0.05) than in those experiencing thromboembolism at other sites. Ovarian hyperstimulation syndrome (OHSS), haemoconcentration and high serum estradiol level were noted in 79, 62 and 54% of women respectively. Forty-eight of 55 patients (87%) who received anticoagulation recovered without sequelae. Among patients willing to continue pregnancy, 32% succeeded in term delivery with all healthy babies, and 23% were ongoing pregnancies. In conclusion, ovarian stimulation cycles accompanying high serum estradiol levels, haemoconcentration or OHSS are at potential risk of thromboembolism. Dose-adjusted heparinization is recommended as the first-line treatment of choice, while intravascular thrombolysis or operative thrombectomy is an aggressive but effective treatment. Continuation of pregnancy is considered safe, without any increased risk of fetal congenital anomalies.

Key words: intracranial thrombectomy/IVF/ovarian hyperstimulation syndrome/thromboembolism


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