Human Reproduction, Vol. 18, No. 11, 2450-2453,
November 2003
© 2003 European Society of Human Reproduction and Embryology
Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles
Infertility Unit, Department of Obstetrics and Gynecology, Clinica ‘L. Mangiagalli’, University of Milan, Milan, Italy
1 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Via Commenda 12, 20122, Milano, Italy. e-mail: dadosomigliana{at}yahoo.it
BACKGROUND: Residual ovarian function after laparoscopic excision of endometriotic ovarian cysts is a major and still unsolved topic. Ultrasonographic evaluation of ovarian response to ovulation stimulation represents a simple yet poorly employed tool to assess residual ovarian function after surgery. METHODS: Data from patients referred for IVF or ICSI between January 2001 and December 2002 were reviewed. Patients were included who previously underwent laparoscopic excision of a monolateral endometriotic ovarian cyst. The operated ovary and contralateral intact ovary were compared in terms of number of follicles with a mean diameter >15 mm at the time of hCG administration. Basal volume of the two ovaries before initiating stimulation was also compared. A paired Student’s t-test was used to investigate differences between the two ovaries. RESULTS: In total, 32 patients and 46 cycles were identified. The mean (± SD) number of follicles >15 mm was 4.2 ± 2.5 in the control ovary and 2.0 ± 1.5 in the previously operated ovary (P < 0.001); this corresponded to a mean reduction of 53% (95% CI 35–72%) but did not seem to be related to the dimension of the excised ovarian cyst. The basal volume of the operated ovaries was also statistically significantly diminished, though this reduction was less relevant. CONCLUSIONS: Excision of endometriotic ovarian cysts is associated with a significant reduction in ovarian reserve. Further studies are required to clarify whether the damage is related to the surgical procedure or to the previous presence of a cyst.
Key words: cyst enucleation/laparoscopy/ovarian cyst/ovarian reserve
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S.-W. Guo Epigenetics of endometriosis Mol. Hum. Reprod., October 1, 2009; 15(10): 587 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Shen, X. Liu, J.-G. Geng, and S.-W. Guo Increased Immunoreactivity to SLIT/ROBO1 in Ovarian Endometriomas: A Likely Constituent Biomarker for Recurrence Am. J. Pathol., August 1, 2009; 175(2): 479 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-W. Guo Recurrence of endometriosis and its control Hum. Reprod. Update, July 1, 2009; 15(4): 441 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vercellini, E. Somigliana, P. Vigano, A. Abbiati, G. Barbara, and P. G. Crosignani Surgery for endometriosis-associated infertility: a pragmatic approach Hum. Reprod., February 1, 2009; 24(2): 254 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Somigliana, M. Arnoldi, L. Benaglia, R. Iemmello, A. E. Nicolosi, and G. Ragni IVF-ICSI outcome in women operated on for bilateral endometriomas Hum. Reprod., July 1, 2008; 23(7): 1526 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Somigliana, P. Vercellini, P. Vigano, G. Ragni, and P. G. Crosignani Should endometriomas be treated before IVF-ICSI cycles? Hum. Reprod. Update, January 1, 2006; 12(1): 57 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Muzii, F. Bellati, A. Bianchi, I. Palaia, N. Manci, M. A. Zullo, R. Angioli, and P. B. Panici Laparoscopic stripping of endometriomas: a randomized trial on different surgical techniques. Part II: pathological results Hum. Reprod., July 1, 2005; 20(7): 1987 - 1992. [Abstract] [Full Text] [PDF]
|
|