Human Reproduction, Vol. 18, No. 11, 2489-2490,
November 2003
© 2003 European Society of Human Reproduction and Embryology
Present options for treating sperm autoimmunity before proteomic analysis is available
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, New Jersey, 7447 Old York Road, Melrose Park, PA 19027, USA. e-mail: laurie@ccivf.com
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Dear Sir,
I would like to commend Drs Bohring and Krause for their excellent treatise of sperm autoimmunity and the value of proteomic analysis. This article provides a detailed clear elucidation of the knowledge concerning this potential infertility factor and provides good insight into where the future is headed in making a specific diagnosis as to which sperm protein is the antibody directed and thus its clinical significance. Once this is known, more specific recommendations for therapy can be made.
As far as present treatment options are concerned, the authors state that currently the first choice is ICSI to overcome the effects of antisperm antibody (ASA) on fertilization. But they also imply that certain autoantibodies may inhibit cervical mucus penetration but not adversely affect fertilization.
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