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Human Reproduction, Vol. 18, No. 2, 229-235, February 2003
© 2003 European Society of Human Reproduction and Embryology

Safety issues in assisted reproduction technology

Should men undergoing ICSI be screened for chromosome abnormalities in their sperm?

D.K. Griffin1,3, P. Hyland1, H.G. Tempest1 and S.T. Homa2

1 Cell and Chromosome Biology Group, Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH and 2 10, Harley Street, London W1G 9PF, UK

3 To whom correspondence should be addressed. e-mail: darren.griffin{at}brunel.ac.uk

The incidence of aneuploidy in gametes of men undergoing ICSI has raised the prospect of there being risks associated with ICSI and the question of whether or not to screen men for sperm aneuploidy before treatment. We report results of a questionnaire undertaken to address how IVF staff perceive this problem, whether ICSI men are already being screened for sperm aneuploidy and the extent to which IVF specialists feel that there is merit in such a test. The results suggest that this is seen as a problem but most feel the risks outweigh the benefits. Most claimed their clinics do not screen sperm for aneuploidy but feel that there is merit in doing so. There are considerable benefits to screening i.e. couples would get additional information about the genetic repercussions of ICSI and could make informed decisions before treatment; screening would also facilitate the design of a large research study to give clearer answers on the safety of ICSI. However, we acknowledge counter arguments i.e. families would not necessarily benefit as most would have the ICSI procedure regardless of screen results; sex chromosome trisomies clinically are not severe enough to worry about in this context and there are other potential risks of ICSI that screening would not address.

Key words: aneuploidy/ICSI/OAT/opinions/sperm


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