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Human Reproduction, Vol. 18, No. 3, 472-473, March 2003
© 2003 European Society of Human Reproduction and Embryology

Reproductive semi-cloning respecting biparental origin

A biologically unsound principle

H. Tateno1, K.E. Latham2,4 and R. Yanagimachi3

1 Department of Biological Sciences, Asahikawa Medical College, Asahikawa, Japan, 2 The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, and 3 The Institute for Biogenesis Research and Department of Anatomy and Reproductive Biology, University of Hawaii at Manoa, Honolulu, HI, USA

4 To whom correspondence should be addressed. e-mail: klatham{at}unix.temple.edu

The original debate article proposed the use of ‘semi-cloning’ as a viable method for assisted reproduction. This debate counters the proposal as being biologically unsound. Given the fundamental limitations of chromosomal segregation and genomic imprinting, the notion of using the MII oocyte to drive haploidization of a somatic cell genome and thereby obtain a substitute for authentic gametes is ill-conceived and untenable.

Key words: assisted reproduction/cloning/gamete reconstruction/haploidization


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