Human Reproduction, Vol. 18, No. 4, 821-825,
April 2003
© 2003 European Society of Human Reproduction and Embryology
Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures
1 Infertility Clinic, The Family Federation of Finland, Kalevankatu 16A, FIN-00100 Helsinki, and 2 Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland
3 To whom correspondence should be addressed. e-mail: andres.salumets{at}vaestoliitto.fi
BACKGROUND: The reduction of multiple pregnancies by using elective single embryo transfers (eSET) requires critical and careful selection of the embryo for transfer. The current study was undertaken to assess whether early cleavage could be used as a marker of embryo competence in eSET procedures. METHODS: The study included analysis of 178 eSET procedures. All embryos were checked for early cleavage at 25–27 h post insemination or ICSI. The embryos that possessed two cells at 25–27 h post insemination or ICSI were designated as ‘early cleavage’ (EC) embryos and those that had not yet cleaved were classified as ‘no early cleavage’ (NEC) embryos. Selection of the embryo for transfer was based on embryo morphology and growth rate on day 2 and not early cleavage. Clinical parameters were compared between 72 EC and 106 NEC single embryo transfers. RESULTS: A significantly higher clinical pregnancy rate was observed after transfer of EC (50%) than NEC (26.4%) embryos. CONCLUSIONS: The current study provides compelling evidence that EC embryos possess significantly higher developmental competence than NEC embryos.
Key words: early cleavage/embryo viability/ICSI/IVF/single embryo transfer
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. A. VandeVoort, N. R. Mtango, Y. S. Lee, G. W. Smith, and K. E. Latham Differential Effects of Follistatin on Nonhuman Primate Oocyte Maturation and Pre-Implantation Embryo Development In Vitro Biol Reprod, December 1, 2009; 81(6): 1139 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Y. Fujimoto, J. P. Kane, B. Y. Ishida, M. S. Bloom, and R. W. Browne High-density lipoprotein metabolism and the human embryo Hum. Reprod. Update, August 28, 2009; (2009) dmp029v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-B. Lee, A. Bettegowda, G. Wee, J. J. Ireland, and G. W. Smith Molecular Determinants of Oocyte Competence: Potential Functional Role for Maternal (Oocyte-Derived) Follistatin in Promoting Bovine Early Embryogenesis Endocrinology, May 1, 2009; 150(5): 2463 - 2471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.G. Vergouw, L.L. Botros, P. Roos, J.W. Lens, R. Schats, P.G.A. Hompes, D.H. Burns, and C.B Lambalk Metabolomic profiling by near-infrared spectroscopy as a tool to assess embryo viability: a novel, non-invasive method for embryo selection Hum. Reprod., July 1, 2008; 23(7): 1499 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P.A. van Montfoort, J. P.M. Geraedts, J. C.M. Dumoulin, A. P.M. Stassen, J. L.H. Evers, and T. A.Y. Ayoubi Differential gene expression in cumulus cells as a prognostic indicator of embryo viability: a microarray analysis Mol. Hum. Reprod., March 1, 2008; 14(3): 157 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J Booth, T. J Watson, and H. J Leese Prediction of Porcine Blastocyst Formation Using Morphological, Kinetic, and Amino Acid Depletion and Appearance Criteria Determined During the Early Cleavage of In Vitro-Produced Embryos Biol Reprod, November 1, 2007; 77(5): 765 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Guerif, A. Le Gouge, B. Giraudeau, J. Poindron, R. Bidault, O. Gasnier, and D. Royere Limited value of morphological assessment at days 1 and 2 to predict blastocyst development potential: A prospective study based on 4042 embryos Hum. Reprod., July 1, 2007; 22(7): 1973 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tang, J. Catt, and D. Howlett Towards defining parameters for a successful single embryo transfer in frozen cycles Hum. Reprod., May 1, 2006; 21(5): 1179 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thurin, T. Hardarson, J. Hausken, B. Jablonowska, K. Lundin, A. Pinborg, and C. Bergh Predictors of ongoing implantation in IVF in a good prognosis group of patients Hum. Reprod., July 1, 2005; 20(7): 1876 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M.R. Gerris Single embryo transfer and IVF/ICSI outcome: a balanced appraisal Hum. Reprod. Update, March 1, 2005; 11(2): 105 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Staessen, P. Platteau, E. Van Assche, A. Michiels, H. Tournaye, M. Camus, P. Devroey, I. Liebaers, and A. Van Steirteghem Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial Hum. Reprod., December 1, 2004; 19(12): 2849 - 2858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P.A. Van Montfoort, J. C.M. Dumoulin, A. D.M. Kester, and J. L.H. Evers Early cleavage is a valuable addition to existing embryo selection parameters: a study using single embryo transfers Hum. Reprod., September 1, 2004; 19(9): 2103 - 2108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Windt, T.F. Kruger, K. Coetzee, and C.J. Lombard Comparative analysis of pregnancy rates after the transfer of early dividing embryos versus slower dividing embryos Hum. Reprod., May 1, 2004; 19(5): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tiitinen, L. Unkila-Kallio, M. Halttunen, and C. Hyden-Granskog Impact of elective single embryo transfer on the twin pregnancy rate Hum. Reprod., July 1, 2003; 18(7): 1449 - 1453. [Abstract] [Full Text] [PDF]
|
|