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Human Reproduction, Vol. 18, No. 5, 955-958, May 2003
© 2003 European Society of Human Reproduction and Embryology

A study of teratogenicity of hydrosalpinx fluid using a whole rat embryo culture model

L.Y. Chan1,3, P.Y. Chiu1, L.P. Cheung1, C.J. Haines1, H.F. Tung2 and T.K. Lau1

1 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong and 2 Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Kowloon, Hong Kong, People’s Republic of China

3 To whom correspondence should be addressed. e-mail: lyschan{at}cuhk.edu.hk

BACKGROUND: Hydrosalpinx fluid may be toxic to sperm and early embryo growth. Information concerning the effect of hydrosalpinx fluid on embryo development during organogenesis is lacking. METHODS: Rat embryos at gestational day 9.5 were cultured for 48 h with 80% rat serum and 20% of either hydrosalpinx fluid (study group) or lactated Ringer’s solution (control group). Embryos were scored for growth and development at the end of the culture period. RESULTS: Hydrosalpinx fluid, collected from 10 patients, was tested for embryotoxicity individually. Median total morphological scores were significantly lower in embryos exposed to hydrosalpinx fluid from three of the 10 patients (43.0 versus 47.0, P = 0.01; 36.0 versus 45.0, P < 0.001; 36.0 versus 46.5, P = 0.003). This was accompanied by a significant reduction in median yolk sac diameter (4.0 versus 5.2 mm, P < 0.001 and 4.0 versus 5.0 mm, P < 0.001) and somite number (17.5 versus 22.5, P < 0.001 and 17.0 versus 21.5, P = 0.008) in the latter two patients. CONCLUSIONS: Hydrosalpinx fluid in some patients may contain toxin(s) that is potentially teratogenic.

Key words: hydrosalpinx/teratogenicity/whole rat embryo culture


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E. H. Y. Ng and L. C. Ajonuma
Teratogenic effect of hydrosalpinx fluid in humans?
Hum. Reprod., October 1, 2003; 18(10): 2237 - 2237.
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