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Human Reproduction, Vol. 18, No. 5, 980-984, May 2003
© 2003 European Society of Human Reproduction and Embryology

Cardiovascular risk factors in young Czech females with polycystic ovary syndrome

J. Vrbíková1,5, R. Cífková2, A. Jirkovská3, V. Lánská4, H. Platilová1, V. Zamrazil1 and L. Stárka1

1 Department of Clinical Endocrinology, Institute of Endocrinology, Národní 8, 116 94 Prague 1, 2 Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Vídenská 1958/9, 140 21 Prague 4, 3 Department of Diabetes, Institute for Clinical and Experimental Medicine, Vídenská 1958/9, 140 21 Prague 4 and 4 Statistics Unit, Institute for Clinical and Experimental Medicine, Vídenská 1958/9, 140 21 Prague 4, Czech Republic

5 To whom correspondence should be addressed at: Národní 8, 116 94 Prague 1, Czech Republic. e-mail: jvrbikova{at}endo.cz

BACKGROUND: Polycystic ovary syndrome (PCOS) could be associated with a variety of signs of metabolic syndrome. The aim of our study was to compare the cardiovascular risk factors in PCOS women and in a control group selected from a random population sample. METHODS AND RESULTS: 50 PCOS women with a mean (±SD) age of 30.7 ± 4.2 years, and 335 controls with a mean age of 29.9 ± 3.1 years selected from a random population sample of nine districts of the Czech Republic were compared for basic anthropometric characteristics, blood pressure, plasma lipids and fasting glucose. PCOS women had a significantly higher body mass index (BMI). After adjusting for BMI, PCOS women had higher blood pressure and LDL-cholesterol, and lower HDL and HDL-cholesterol/total ratio. Arterial hypertension was more prevalent in PCOS women than in controls. There was no difference in the prevalence of impaired fasting glucose between both groups. Impaired glucose tolerance was found in 11.8% of PCOS women. Diabetes mellitus was more frequent in PCOS families. CONCLUSIONS: Czech PCOS women, even in their thirties, show a significantly worse cardiovascular risk profile than a control group selected from a random population sample. The differences cannot be explained by obesity.

Key words: dyslipidaemia/hypertension/impaired glucose tolerance/type-2 diabetes mellitus


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