Human Reproduction, Vol. 19, No. 1, 179-184,
January 2004
© 2004 European Society of Human Reproduction and Embryology
The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease
Department of Obstetrics and Gynaecology, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
1 To whom correspondence should be addressed. e-mail: jck4{at}le.ac.uk
BACKGROUND: Medical treatment of endometriosis, a condition which significantly affects the quality of life in 
10–15% of women in the reproductive years, remains problematic. Although oral progestogens are effective and cheap, their efficacy is significantly influenced by poor compliance and systemic side effects. A progestogen (levonorgestrel) administered via an intrauterine system (Lng-IUS) has been demonstrated to improve symptoms of endometriosis; however, its effect on the staging of the disease has not been evaluated. The aims of this study were therefore to investigate the effectiveness of Lng-IUS in the symptomatic relief of minimal to moderate endometriosis and in the staging of the disease. METHODS: This was a prospective non-comparative observational study in which 34 women with clinically suspected and laparoscopically confirmed symptomatic minimal to moderate endometriosis had Lng-IUS inserted for 6 months. The symptom profile and stage of the disease before, during and after 6 months of treatment and patients’ satisfaction with treatment and willingness to retain the device at the end of the study period were used to assess response to treatment. RESULTS: Of the 34 women recruited, 29 (85%) completed the study; five discontinued, for personal reasons (one), side effects of worsening of acne (one) and lower abdominal/ pelvic pain (three). Significant (P < 0.05) improvements in severity and frequency of pain and menstrual symptoms as well as staging were achieved, with 68% (23) of cases electing to continue with the device after 6 months of therapy. CONCLUSION: The levonorgestrel intrauterine system is an effective hormonal option for treating symptomatic endometriosis (minimal to moderate). It also alters the American Fertility Society staging of disease. With a continuation rate of 68% after 6 months, it has the potential for providing long-term therapy in a substantial number of sufferers, although this would require further study and verification.
Key words: endometriosis/levonorgestrel-releasing intrauterine system/mirena
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Yuan, Y. Huang, H. Wu, Z. Teng, J. Zhang, and X. Xin Induction of a local pseudo-pregnancy via levonorgestrel-loaded microspheres for the treatment of endometriosis in a rabbit model Hum. Reprod., November 7, 2009; (2009) dep386v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The ESHRE Capri Workshop Group Intrauterine devices and intrauterine systems Hum. Reprod. Update, May 1, 2008; 14(3): 197 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Crosignani, D. Olive, A. Bergqvist, and A. Luciano Advances in the management of endometriosis: an update for clinicians Hum. Reprod. Update, March 1, 2006; 12(2): 179 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Petta, R. A. Ferriani, M. S. Abrao, D. Hassan, J. C. Rosa e Silva, S. Podgaec, and L. Bahamondes Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis Hum. Reprod., July 1, 2005; 20(7): 1993 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. B. Lockhat, J. O. Emembolu, and J. C. Konje The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up Hum. Reprod., March 1, 2005; 20(3): 789 - 793. [Abstract] [Full Text] [PDF]
|
|