Human Reproduction, Vol. 19, No. 1, 41-47,
January 2004
© 2004 European Society of Human Reproduction and Embryology
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
Correspondence to: Bart C.J.M.Fauser, Center of Reproductive Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands. e-mail: b.fauser{at}erasmusmc.nl
Since the 1990 NIH-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome and, as such, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include: menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.
Key words: diagnostic criteria/long-term health risks/polycystic ovary syndrome/revised 2003 consensus
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 L. J Moran, M. Noakes, P. M Clifton, G. A Wittert, C. W Le Roux, M. A Ghatei, S. R Bloom, and R. J Norman Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1603 - 1610. [Abstract] [Full Text] [PDF]
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K. E. S. Salley, E. P. Wickham, K. I. Cheang, P. A. Essah, N. W. Karjane, and J. E. Nestler POSITION STATEMENT: Glucose Intolerance in Polycystic Ovary Syndrome A Position Statement of the Androgen Excess Society J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4546 - 4556. [Abstract] [Full Text] [PDF]
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M.-G. Li, G.-L. Ding, X.-J. Chen, X.-P. Lu, L.-J. Dong, M.-Y. Dong, X.-F. Yang, X.-E Lu, and H.-F. Huang Association of Serum and Follicular Fluid Leptin Concentrations with Granulosa Cell Phosphorylated Signal Transducer and Activator of Transcription 3 Expression in Fertile Patients with Polycystic Ovarian Syndrome J. Clin. Endocrinol. Metab., December 1, 2007; 92(12): 4771 - 4776. [Abstract] [Full Text] [PDF]
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M. Luque-Ramirez, C. Mendieta-Azcona, F. Alvarez-Blasco, and H. F. Escobar-Morreale Androgen excess is associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome Hum. Reprod., December 1, 2007; 22(12): 3197 - 3203. [Abstract] [Full Text] [PDF]
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P. M. Lam, I. R. Johnson, and N. J. Raine-Fenning Three-dimensional ultrasound features of the polycystic ovary and the effect of different phenotypic expressions on these parameters Hum. Reprod., December 1, 2007; 22(12): 3116 - 3123. [Abstract] [Full Text] [PDF]
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S. Tan, S. Hahn, S. Benson, T. Dietz, H. Lahner, L. C Moeller, M. Schmidt, S. Elsenbruch, R. Kimmig, K. Mann, et al. Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance Eur. J. Endocrinol., November 1, 2007; 157(5): 669 - 676. [Abstract] [Full Text] [PDF]
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S. Catteau-Jonard, P. Pigny, A.-C. Reyss, C. Decanter, E. Poncelet, and D. Dewailly Changes in Serum Anti-Mullerian Hormone Level during Low-Dose Recombinant Follicular-Stimulating Hormone Therapy for Anovulation in Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4138 - 4143. [Abstract] [Full Text] [PDF]
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E. Moll, F. van der Veen, and M. van Wely The role of metformin in polycystic ovary syndrome: a systematic review Hum. Reprod. Update, November 1, 2007; 13(6): 527 - 537. [Abstract] [Full Text] [PDF]
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