Human Reproduction, Vol. 19, No. 1, 41-47,
January 2004
© 2004 European Society of Human Reproduction and Embryology
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
Correspondence to: Bart C.J.M.Fauser, Center of Reproductive Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands. e-mail: b.fauser{at}erasmusmc.nl
Since the 1990 NIH-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome and, as such, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include: menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.
Key words: diagnostic criteria/long-term health risks/polycystic ovary syndrome/revised 2003 consensus
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