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Hum. Reprod. Advance Access originally published online on July 8, 2004
Human Reproduction 2004 19(10):2244-2250; doi:10.1093/humrep/deh406
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Human Reproduction vol. 19 no. 10 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Laparoscopic electrocautery of the ovaries versus recombinant FSH in clomiphene citrate-resistant polycystic ovary syndrome. Impact on women's health-related quality of life

M. van Wely1,3, N. Bayram1, P.M.M. Bossuyt2 and F. van der Veen1

1 Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology (H4-205), Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands and 2 Department of Clinical Epidemiology and Biostatistics

3 To whom correspondence should be addressed. Email: m.vanwely{at}amc.uva.nl

BACKGROUND: Ovulation induction with gonadotrophins is the standard treatment strategy for women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). Laparoscopic electrocautery of the ovaries is an alternative treatment modality, leading to a comparable cumulative pregnancy rate. In deciding which treatment to opt for, women's health-related quality of life (HRQoL) should be taken into account. METHODS: A total of 168 CC-resistant women with PCOS were randomly assigned to receive either the electrocautery strategy, entailing laparoscopic electrocautery of the ovaries followed by CC and recombinant FSH (rFSH) if anovulation persisted, or ovulation induction with rFSH. We assessed women's HRQoL with the standard questionnaires Short Form-36, Rotterdam Symptom Checklist and Center for Epidemiological Studies Depression Scale, administered before randomization and 2, 12 and 24 weeks thereafter. RESULTS: The intention to treat analysis revealed no significant differences between the treatment groups on any of the scales at any point during follow-up. In women without an ongoing pregnancy, those treated with rFSH showed significantly more depressive symptoms than women allocated to the electrocautery strategy, with or without CC, although differences were small. CONCLUSIONS: Overall, HRQoL was not affected in both groups. In women still under treatment, rFSH was slightly more burdensome for women's HRQoL than electrocautery with or without CC.

Key words: health-related quality of life/laparoscopic electrocautery/ovulation induction/PCOS/randomized controlled trial


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 Hum Reprod UpdateHome page
G.L. Jones, J.M. Hall, A.H. Balen, and W.L. Ledger
Health-related quality of life measurement in women with polycystic ovary syndrome: a systematic review
Hum. Reprod. Update, January 1, 2008; 14(1): 15 - 25.
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